Evidence map›Paper›PMID 33207785›Full record

ArticleCancers2020

Outcome After 68Ga-PSMA-11 versus Choline PET-Based Salvage Radiotherapy in Patients with Biochemical Recurrence of Prostate Cancer: A Matched-Pair Analysis.

Nina-Sophie Schmidt Hegemann, Paul Rogowski, Chukwuka Eze, Christian Schäfer, Christian Stief, Sebastian Lang, Simon Spohn, Rieke Steffens, Minglun Li, Christian Gratzke and 11 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Lancet (London, England) · 2021
    Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Detection of recurrence sites usingProstate international · 2023
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 2 countries.

Nina-Sophie Schmidt HegemannDepartment of Radiation Oncology, University Hospital, 81377 LMU Munich, Germany.
Paul RogowskiDepartment of Radiation Oncology, University Hospital, 81377 LMU Munich, Germany.ORCID 0000-0003-3351-8896
Chukwuka EzeDepartment of Radiation Oncology, University Hospital, 81377 LMU Munich, Germany.ORCID 0000-0003-3779-1398
Christian SchäferDepartment of Radiation Oncology, University Hospital, 81377 LMU Munich, Germany.ORCID 0000-0002-5382-5933
Christian StiefDepartment of Urology, University Hospital, 81377 LMU Munich, Germany.
Sebastian LangDepartment of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0001-7562-9223
Simon SpohnDepartment of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Rieke SteffensDepartment of Radiation Oncology, University Hospital, 81377 LMU Munich, Germany.
Minglun LiDepartment of Radiation Oncology, University Hospital, 81377 LMU Munich, Germany.ORCID 0000-0002-7312-8350
Christian GratzkeDepartment of Urology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Wolfgang Schultze-SeemannDepartment of Urology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Harun IlhanDepartment of Nuclear Medicine, University Hospital, 81377 LMU Munich, Germany.
Wolfgang Peter FendlerDepartment of Nuclear Medicine, University of Duisburg-Essen, 47057 Essen, Germany.
Peter BartensteinDepartment of Nuclear Medicine, University Hospital, 81377 LMU Munich, Germany.
Ute GanswindtDepartment of Therapeutic Radiology and Oncology, Innsbruck Medical University, 6020 Innsbruck, Austria.
Alexander BuchnerDepartment of Urology, University Hospital, 81377 LMU Munich, Germany.ORCID 0000-0001-7895-7070
Anca-Ligia GrosuDepartment of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Claus BelkaDepartment of Radiation Oncology, University Hospital, 81377 LMU Munich, Germany.
Philipp Tobias MeyerDepartment of Nuclear Medicine, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Simon KirsteDepartment of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Constantinos ZamboglouDepartment of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
LMU Klinikum · DEUniversity of Freiburg · DEEssen University Hospital · DEGerman Cancer Research Center · DEInnsbruck Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of this analysis was primarily to analyze biochemical-recurrence free survival (BRFS) after positron emission tomography (PET)-guided salvage radiotherapy (sRT) in a large cohort, and to further compare BRFS after PSMA vs. choline PET/ computer tomography (CT)-based sRT. This retrospective analysis is based on 421 patients referred for PSMA or choline PET/CT after radical prostatectomy due to biochemically recurrent or persistent disease. BRFS (PSA: 0.2 ng/mL) was defined as the study endpoint. Cox regression analyses were performed to assess the impact of different clinical parameters on BRFS. Additionally, propensity score matching was performed to adjust patient cohorts (PSMA vs. choline PET/CT-based sRT). The median follow-up time was 30 months. BRFS at three years after sRT was 58%. In the multivariate analysis, only PSA before PET imaging and PSA before sRT were significantly associated with BRFS (

Indexed as

choline PET/CTmatched-pairs analysisprostate cancerPSMA PET/CTsalvage radiotherapy

Identifiers

PMID33207785
PMCPMC7698293
OpenAlexW3104665794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.