Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells.

Nadin Shagaghi, Andrew H A Clayton, Marie-Isabel Aguilar, Tzong-Hsien Lee, Enzo A Palombo, Mrinal Bhave

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

1.1field-weighted citation impact, top 24% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

Creation of New Antimicrobial Peptides.International journal of molecular sciences · 2023
Article
Scorpion Venom Antimicrobial Peptides Induce Siderophore Biosynthesis and Oxidative Stress Responses in Escherichia coli.mSphere · 2021
Article
Inhibitory Effect of Puroindoline Peptides onFrontiers in microbiology · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nadin ShagaghiDepartment of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, PO Box 218, Hawthorn, VIC 3122, Australia.

Andrew H A ClaytonCentre for Micro-Photonics, Faculty of Science, Engineering and Technology, Swinburne University of Technology, PO Box 218, Hawthorn, VIC 3122, Australia.

Marie-Isabel AguilarDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-0234-4064

Tzong-Hsien LeeDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.

Enzo A PalomboDepartment of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, PO Box 218, Hawthorn, VIC 3122, Australia.ORCID 0000-0001-5889-1393

Mrinal BhaveDepartment of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, PO Box 218, Hawthorn, VIC 3122, Australia.

Swinburne University of Technology · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) often exhibit wide-spectrum activities and are considered ideal candidates for effectively controlling persistent and multidrug-resistant wound infections. PuroA, a synthetic peptide based on the tryptophan (Trp)-rich domain of the wheat protein puroindoline A, displays strong antimicrobial activities. In this work, a number of peptides were designed based on PuroA, varying in physico-chemical parameters of length, number of Trp residues, net charge, hydrophobicity or amphipathicity, D-versus L-isomers of amino acids, cyclization or dimerization, and were tested for antimicrobial potency and salt and protease tolerance. Selected peptides were assessed for effects on biofilms of methicillin-resistant

Indexed as

Antineoplastic AgentsPore Forming Cytotoxic ProteinsAnimalsBiofilmsDrug Screening Assays, AntitumorHeLa CellsHumansMethicillin-Resistant Staphylococcus aureusMiceNIH 3T3 CellsSheepAntineoplastic AgentsPore Forming Cytotoxic Proteinsanticancer peptidesantimicrobial peptidescationic peptidespuroindoline Atryptophan rich peptides

Identifiers

PMID33207639

DOI10.3390/ijms21228624

PMCPMC7696940

OpenAlexW3101118629

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.