Evidence map›Paper›PMID 33207637›Full record

ReviewMolecules (Basel, Switzerland)2020

Structure-Function Insights of Jaburetox and Soyuretox: Novel Intrinsically Disordered Polypeptides Derived from Plant Ureases.

Matheus V Coste Grahl, Fernanda Cortez Lopes, Anne H Souza Martinelli, Celia R Carlini, Leonardo L Fruttero

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Matheus V Coste GrahlGraduate Program in Medicine and Health Sciences, Brain Institute of Rio Grande do Sul (InsCer), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre CEP 90610-000, Brazil.ORCID 0000-0002-4935-5211
Fernanda Cortez LopesGraduate Program in Cellular and Molecular Biology, Center of Biotechnology, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9500, Building 43431, Porto Alegre CEP 91501-970, RS, Brazil.ORCID 0000-0003-1718-3467
Anne H Souza MartinelliDepartment of Biophysics & Deparment of Molecular Biology and Biotechnology-Biosciences Institute (IB), Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre 91501-970, RS, Brazil.
Celia R CarliniGraduate Program in Medicine and Health Sciences, Brain Institute of Rio Grande do Sul (InsCer), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre CEP 90610-000, Brazil.ORCID 0000-0002-7027-2445
Leonardo L FrutteroDepartamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba CP 5000, Argentina.ORCID 0000-0001-9031-8474
Instituto do Cérebro · BRUniversidade Federal do Rio Grande do Sul · BRConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico proj. 44.6052/2014-1; Edital Jovem Talento-BJT 40.0189/2014-3, Science Without BordersCoordenação de Aperfeiçoamento de Pessoal de Nível Superior Finance Code 001, Edital Toxinologia 63/2010 proj. 1205/2011; Portal de PeriódicosFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul Edital PRONEX 008/2009, proj. 10/0014-2
6 · The paper itself

Abstract

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) do not have a stable 3D structure but still have important biological activities. Jaburetox is a recombinant peptide derived from the jack bean (Canavalia ensiformis) urease and presents entomotoxic and antimicrobial actions. The structure of Jaburetox was elucidated using nuclear magnetic resonance which reveals it is an IDP with small amounts of secondary structure. Different approaches have demonstrated that Jaburetox acquires certain folding upon interaction with lipid membranes, a characteristic commonly found in other IDPs and usually important for their biological functions. Soyuretox, a recombinant peptide derived from the soybean (

Indexed as

Amino Acid SequenceIntrinsically Disordered ProteinsPeptidesPesticidesPlant ProteinsStructure-Activity RelationshipUreaseIntrinsically Disordered Proteinsjaburetox-2Ec, Canavalia ensiformisPeptidesPesticidesPlant ProteinsUreaseantifungal activitybiopesticidesinsecticidal activitymechanism of actiontransgenic crops

Identifiers

PMID33207637
PMCPMC7696265
OpenAlexW3101407933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.