ArticleCell metabolism2020
Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T
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Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
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Who cites it
46 citing papers in PubMed, 56 citations in OpenAlex.
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- The transcription factor SREBP2 supports the activation and homeostasis of CD4+ Foxp3+ regulatory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- LDL receptor-mediated lipoprotein uptake fuels human CD4+ T cell polarization toward a c-MAF/IL-10- and FOXP3-driven phenotype.JCI insight · 2026Article
- Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation.eLife · 2026Article
- Simvastatin Alleviates ConA-Induced Autoimmune Hepatitis by Inhibiting CD4Inflammation · 2026Article
- Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cells.Science immunology · 2025Article
- Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition.BMC biology · 2025Article
- Article
- Immunometabolism of regulatory T cells in cancer.Oncogene · 2025Review
- Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics.Molecular cancer · 2025Review
- Vps34-orchestrated lipid signaling processes regulate the transitional heterogeneity and functional adaptation of effector regulatory T cells.PLoS biology · 2025Article
- Bridging epigenomics and tumor immunometabolism: molecular mechanisms and therapeutic implications.Molecular cancer · 2025Review
- Gluconolactone restores immune regulation and alleviates skin inflammation in lupus-prone mice and in patients with cutaneous lupus.Science translational medicine · 2025Article
- Regulation of Adaptive Immunity by Lipid Post-translational Modifications.Immune network · 2025Review
- Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis.Science immunology · 2025Article
- Trained immunity in atherosclerosis: plasticity, metabolic-vascular axis, and AI-driven precision remodeling.Frontiers in immunology · 2025Review
- Bidirectional regulation of lipid metabolism and the tumor microenvironment: new perspectives from mechanism to therapy.Frontiers in immunology · 2025Review
- Geranylgeranyl Pyrophosphate Promotes Profibrotic Factors and Collagen-Specific Chaperone HSP47 in Fibroblasts.Journal of cellular and molecular medicine · 2024Article
- Dynamic transition of Tregs to cytotoxic phenotype amid systemic inflammation in Graves' ophthalmopathy.JCI insight · 2024Article
- Regulation of CD8+ T cells by lipid metabolism in cancer progression.Cellular & molecular immunology · 2024Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Wei SuDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Science Program, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Nicole M ChapmanDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jun WeiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hu ZengDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yogesh DhunganaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hao ShiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jordy SaraviaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peipei ZhouDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lingyun LongDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sherri RankinDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Anil KcDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peter VogelDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Hongbo ChiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: hongbo.chi@stjude.org.
St. Jude Children's Research Hospital · US
Funding
Regulation of TH17 plasticity and stemness by mTORC1R01AI131703 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$4.1MTranscriptional and metabolic heterogeneity in T cell differentiationR01AI140761 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2018 to 2026
$3.9MMetabolic checkpoint in dendritic cell subsets and adaptive immunityR37AI105887 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.6MBidirectional signaling in T cell differentiationR01AI150241 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Hongbo Chi · 2019 to 2026
$3.3MNutrient sensing and lysosomal signaling in regulatory T cells and immune toleranceR01AI150514 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2019 to 2023
$2.2MMetabolic reprogramming of Tregs in tumor immunityR01CA221290 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2017 to 2020
$1.6MReprogram long-lived effector T cells for cancer immunotherapyR01CA250533 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHI, HONGBO · 2020 to 2021
$1.2MNCI NIH HHS R01 CA221290NCI NIH HHS R01 CA250533NIAID NIH HHS R01 AI131703NIAID NIH HHS R01 AI140761NIAID NIH HHS R01 AI150241NIAID NIH HHS R01 AI150514NIAID NIH HHS R37 AI105887
Abstract
Effector regulatory T (eT
Indexed as
TerpenesT-Lymphocytes, RegulatoryAnimalsCell DifferentiationFemaleImmune ToleranceLymphocyte ActivationMaleMiceMice, Inbred C57BLMice, KnockoutProtein PrenylationTerpenesFntbimmunometabolismmTORPggt1bprotein prenylationTreg cells
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.