Evidence map›Paper›PMID 33207199›Full record

ArticleCell reports2020

Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17.

Jingwen Niu, Shaun S Sanders, Hey-Kyeong Jeong, Sabrina M Holland, Yue Sun, Kaitlin M Collura, Luiselys M Hernandez, Haoliang Huang, Michael R Hayden, George M Smith and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 43 citations in OpenAlex.

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  16. An intraflagellar transport dependent negative feedback regulates the MAPKKK DLK-1 to protect cilia from degeneration.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Jingwen NiuShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
Shaun S SandersShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
Hey-Kyeong JeongShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
Sabrina M HollandShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
Yue SunSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Kaitlin M ColluraShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
Luiselys M HernandezShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA.
Haoliang HuangDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Michael R HaydenDepartment of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
George M SmithShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA; Department of Neuroscience, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Yang HuDepartment of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Yishi JinSection of Neurobiology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Gareth M ThomasShriners Hospitals Pediatric Research Center, Lewis Katz School of Medicine at Temple University, 3500 N. Broad Street, Philadelphia, PA 19140, USA; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA. Electronic address: gareth.thomas@temple.edu.
Temple University Hospital · USStanford University · USUniversity of California San Diego · USTemple University · USUniversity of British Columbia · CA

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Elucidating Neuron-Intrinsic Molecular Mechanisms of Optic Nerve RegenerationR01EY024932 · NEI · TEMPLE UNIV OF THE COMMONWEALTH · PI Yang Hu · 2015 to 2026
$4.8M
Neuroprotection by Modulating ER Stress in GlaucomaR01EY023295 · NEI · TEMPLE UNIV OF THE COMMONWEALTH · PI HU, YANG · 2013 to 2022
$3.8M
Regulation of Axonal Signaling by PalmitoylationR01NS094402 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI THOMAS, GARETH · 2015 to 2025
$3.7M
GABAergic Neuron Differentiation in C.elegansR37NS035546 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIN, YISHI · 2017 to 2021
$2.4M
Developing Novel Neuroprotective Strategies for EAE/Optic NeuritisR01EY028106 · NEI · STANFORD UNIVERSITY · PI HU, YANG · 2018 to 2021
$1.9M
Palmitoylation-dependent Control of Glaucomatous NeurodegenerationR21EY029386 · NEI · TEMPLE UNIV OF THE COMMONWEALTH · PI THOMAS, GARETH · 2019 to 2020
$454k
NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY023295NEI NIH HHS R01 EY024932NEI NIH HHS R01 EY028106NEI NIH HHS R21 EY029386NINDS NIH HHS R01 NS094402NINDS NIH HHS R37 NS035546
6 · The paper itself

Abstract

After optic nerve crush (ONC), the cell bodies and distal axons of most retinal ganglion cells (RGCs) degenerate. RGC somal and distal axon degenerations were previously thought to be controlled by two parallel pathways, involving activation of the kinase dual leucine-zipper kinase (DLK) and loss of the axon survival factor nicotinamide mononucleotide adenylyltransferase-2 (NMNAT2), respectively. Here, we report that palmitoylation of both DLK and NMNAT2 by the palmitoyl acyltransferase ZDHHC17 couples these signals. ZDHHC17-dependent palmitoylation enables DLK-dependent somal degeneration after ONC and also ensures NMNAT-dependent distal axon integrity in healthy optic nerves. We provide evidence that ZDHHC17 also controls survival-versus-degeneration decisions in dorsal root ganglion (DRG) neurons, and we identify conserved motifs in NMNAT2 and DLK that govern their ZDHHC17-dependent regulation. These findings suggest that the control of somal and distal axon integrity should be considered as a single, holistic process, mediated by the concerted action of two palmitoylation-dependent pathways.

Indexed as

AcyltransferasesAnimalsAxonsCaenorhabditis elegansCells, CulturedCell SurvivalDisease Models, AnimalGanglia, SpinalHEK293 CellsHumansLipoylationMAP Kinase Kinase KinasesMiceMice, Inbred C57BLNerve DegenerationNicotinamide-Nucleotide AdenylyltransferaseAcyltransferasesMAP Kinase Kinase Kinasesmitogen-activated protein kinase kinase kinase 12Nicotinamide-Nucleotide AdenylyltransferaseNmnat2 protein, mouseZdhhc17 protein, mouseDHHCJNKMAPKSARM1WallerianWlds

Identifiers

PMID33207199
PMCPMC7803378
OpenAlexW3101085860

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.