Evidence map›Paper›PMID 33207013›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2021

Cellular therapies in organ transplantation.

Martin J Hoogduijn, Fadi Issa, Federica Casiraghi, Marlies E J Reinders

Abstract readReview
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Martin J HoogduijnNephrology and Transplantation, Department of Internal Medicine, Erasmus University Medical Center, Erasmus Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-0217-8254
Fadi IssaTransplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Federica CasiraghiIstituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.
Marlies E J ReindersNephrology and Transplantation, Department of Internal Medicine, Erasmus University Medical Center, Erasmus Medical Center, Rotterdam, The Netherlands.

Funding

Medical Research Council MC_PC_18059Medical Research Council MR/N027930/1Wellcome Trust 211122/Z/18/Z
6 · The paper itself

Abstract

Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury-related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the feasibility of efficacious cell therapy in transplantation, early clinical trials have shown safety of several of these therapies, and the first steps towards efficacy studies in humans have been made. In this review, we address the current state of the art of cellular therapies in clinical transplantation and discuss monitoring tools and endpoints for these studies.

Indexed as

Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationOrgan TransplantationCell- and Tissue-Based TherapyGraft RejectionHumanscell therapyimmunomodulationmesenchymal stromal cellsregenerationregulatory macrophagesregulatory T-cells

Identifiers

PMID33207013
PMCPMC7898347

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.