ArticlePLoS biology2020
Hippocampal cells integrate past memory and present perception for the future.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Differential Coding of Associative Memory Information in the Macaque Lateral Prefrontal Cortex and Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Towards a neurodevelopmental cognitive perspective of temporal processing.Communications biology · 2024Review
- A high-density 1,024-channel probe for brain-wide recordings in non-human primates.Nature neuroscience · 2024Article
- Sequential involvements of the perirhinal cortex and hippocampus in the recall of item-location associative memory in macaques.PLoS biology · 2023Article
- Organization of parietoprefrontal and temporoprefrontal networks in the macaque.Journal of neurophysiology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to use stored information in a highly flexible manner is a defining feature of the declarative memory system. However, the neuronal mechanisms underlying this flexibility are poorly understood. To address this question, we recorded single-unit activity from the hippocampus of 2 nonhuman primates performing a newly devised task requiring the monkeys to retrieve long-term item-location association memory and then use it flexibly in different circumstances. We found that hippocampal neurons signaled both mnemonic information representing the retrieved location and perceptual information representing the external circumstance. The 2 signals were combined at a single-neuron level to construct goal-directed information by 3 sequentially occurring neuronal operations (e.g., convergence, transference, and targeting) in the hippocampus. Thus, flexible use of knowledge may be supported by the hippocampal constructive process linking memory and perception, which may fit the mnemonic information into the current situation to present manageable information for a subsequent action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.