ArticleParasite (Paris, France)2020
Molecular identification of Trypanosoma brucei gambiense in naturally infected pigs, dogs and small ruminants confirms domestic animals as potential reservoirs for sleeping sickness in Chad.
Article in Parasite (Paris, France), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 30 citations in OpenAlex.
- Silent transmission of human African trypanosomiasis: isolation of a human-infective trypanosome from an asymptomatic pregnant woman in south-eastern Nigeria.Tropical medicine and health · 2026Article
- Wildlife surveys detectCurrent research in parasitology & vector-borne diseases · 2026Article
- Article
- Bold strides towards the elimination of gambiense human African trypanosomiasis (gHAT) as a public health problem-A case study of Angola.PLoS neglected tropical diseases · 2025Review
- Domestic dogs as reservoirs for African trypanosomiasis in Mambwe district, eastern Zambia.Scientific reports · 2024Article
- Novel trypanosomatid species detected in Mongolian pikas (Ochotona pallasi) and their fleas in northwestern China.Parasites & vectors · 2024Article
- Prevalence of blood and skin trypanosomes in domestic and wild fauna from two sleeping sickness foci in Southern Cameroon.PLoS neglected tropical diseases · 2023Article
- Does a One Health approach to human African trypanosomiasis control hasten elimination? A stochastic compartmental modeling approach.Acta tropica · 2023Article
- Molecular Identification of Trypanosome Diversity in Domestic Animals Reveals the Presence ofPathogens (Basel, Switzerland) · 2022Article
- Modelling to infer the role of animals in gambiense human African trypanosomiasis transmission and elimination in the DRC.PLoS neglected tropical diseases · 2022Article
- Evaluation of the Re-emergence Risk of Human African Trypanosomiasis in the Southwestern Burkina Faso, A Gold-Bearing Mutation Area.Acta parasitologica · 2022Article
- A review on the diagnosis of animal trypanosomoses.Parasites & vectors · 2022Review
- First Report of AnuranPathogens (Basel, Switzerland) · 2022Article
- Prevalence of pathogenic trypanosome species in naturally infected cattle of three sleeping sickness foci of the south of Chad.PloS one · 2022Article
- Free-ranging pigs identified as a multi-reservoir of Trypanosoma brucei and Trypanosoma congolense in the Vavoua area, a historical sleeping sickness focus of Côte d'Ivoire.PLoS neglected tropical diseases · 2021Article
- Diversity of tsetse flies and trypanosome species circulating in the area of Lake Iro in southeastern Chad.Parasites & vectors · 2021Article
- Diversity of trypanosomes in humans and cattle in the HAT foci Mandoul and Maro, Southern Chad-A matter of concern for zoonotic potential?PLoS neglected tropical diseases · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human African trypanosomiasis (HAT) has been targeted for zero transmission to humans by 2030. Animal reservoirs of gambiense-HAT could jeopardize these elimination goals. This study was undertaken to identify potential host reservoirs for Trypanosoma brucei gambiense by detecting its natural infections in domestic animals of Chadian HAT foci. Blood samples were collected from 267 goats, 181 sheep, 154 dogs, and 67 pigs. Rapid diagnostic test (RDT) and capillary tube centrifugation (CTC) were performed to search for trypanosomes. DNA was extracted from the buffy coat, and trypanosomes of the subgenus Trypanozoon as well as T. b. gambiense were identified by PCR. Of 669 blood samples, 19.4% were positive by RDT and 9.0% by CTC. PCR revealed 150 animals (22.4%) with trypanosomes belonging to Trypanozoon, including 18 (12%) T. b. gambiense. This trypanosome was found in all investigated animal species and all HAT foci. Between animal species or villages, no significant differences were observed in the number of animals harboring T. b. gambiense DNA. Pigs, dogs, sheep and goats appeared to be potential reservoir hosts for T. b. gambiense in Chad. The identification of T. b. gambiense in all animal species of all HAT foci suggests that these animals should be considered when designing new control strategies for sustainable elimination of HAT. Investigations aiming to decrypt their specific role in each epidemiological setting are important to achieve zero transmission of HAT.
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