Evidence map›Paper›PMID 33206559›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2021

Skeletal muscle extracellular matrix remodeling with worsening glycemic control in nonhuman primates.

Alistaire D Ruggiero, Ashley Davis, Chrissy Sherrill, Brian Westwood, Gregory A Hawkins, Nicholette D Palmer, Jeff W Chou, Tony Reeves, Laura A Cox, Kylie Kavanagh

Open access · greenAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Alistaire D RuggieroDepartment of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Ashley DavisDepartment of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Chrissy SherrillDepartment of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Brian WestwoodDepartment of Hypertension, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Gregory A HawkinsCenter for Precision Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Nicholette D PalmerCenter for Precision Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Jeff W ChouDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Tony ReevesCenter for Precision Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Laura A CoxDepartment of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.ORCID 0000-0002-8836-3783
Kylie KavanaghDepartment of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Wake Forest University · USUniversity of Tasmania · AU

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Vervet Research Colony as a Biomedical ResourceP40OD010965 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Matthew Jorgensen · 2012 to 2026
$14.6M
TRAINING PROGRAM IN IMMUNOLOGY AND PATHOGENESIST32AI007401 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Martha Ann Alexander-Miller · 1991 to 2026
$4.4M
Adipose Mitochondial Quality Control and Cardiovascular Function in Metabolically Healthy and Unhealthy Obese MonkeysR01HL142930 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KAVANAGH, KYLIE · 2019 to 2023
$3.4M
Age-Related Changes in Intestinal Function and Sarcopenia in MonkeysR21AG049160 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KAVANAGH, KYLIE · 2015 to 2016
$426k
NCI NIH HHS P30 CA012197NHLBI NIH HHS R01 HL142930NIAID NIH HHS T32 AI007401NIA NIH HHS R21 AG049160NIH HHS P40 OD010965
6 · The paper itself

Abstract

Type 2 diabetes (T2D) development may be mediated by skeletal muscle (SkM) function, which is responsible for >80% of circulating glucose uptake. The goals of this study were to assess changes in global- and location-level gene expression, remodeling proteins, fibrosis, and vascularity of SkM with worsening glycemic control, through RNA sequencing, immunoblotting, and immunostaining. We evaluated SkM samples from health-diverse African green monkeys (

Indexed as

AnimalsBiomarkersBlood GlucoseChlorocebus aethiopsDiabetes Mellitus, Type 2Disease Models, AnimalExtracellular MatrixExtracellular Matrix ProteinsFemaleFibrosisGene Expression RegulationGene Regulatory NetworksMicrovascular DensityPrediabetic StateProtein Interaction MapsQuadriceps MuscleBiomarkersBlood GlucoseExtracellular Matrix Proteinscapillarizationextracellular matrix remodelingglucosemetabolic diseaseskeletal muscle

Identifiers

PMID33206559
PMCPMC7988770
OpenAlexW3101168305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.