ArticleJournal of diabetes investigation2021
Association of mean corpuscular volume with sarcopenia and visceral obesity in individuals without anemia.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Biomarkers and the quadriceps femoris muscle architecture assessed by ultrasound in older adults with heart failure with preserved ejection fraction: a cross-sectional study.Aging clinical and experimental research · 2022Trial
- Investigating the Association Between Anemia and Biochemical Factors in Relation to New Anthropometric Metrics in an Iranian Cohort: A Cross-Sectional Study.Health science reports · 2026Article
- Mean Corpuscular Volume inJournal of hematology · 2026Article
- Development and validation of a Four-Year predictive model for sarcopenia in older adults: insights from the CHARLS cohort.Aging clinical and experimental research · 2025Article
- Association of hematological parameters and inflammatory indices with sarcopenia in the United States and China: a cross-sectional study.European journal of medical research · 2025Article
- Causal links of α-thalassemia indices and cardiometabolic traits and diabetes: MR study.Life science alliance · 2023Article
- Association of mean corpuscular volume with sarcopenia and visceral obesity in individuals without anemia.Journal of diabetes investigation · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIMS/
introductionSarcopenia and visceral obesity are major global public health issues, and higher mean corpuscular volume (MCV) levels are related to adverse outcomes. Nevertheless, no study has determined the association between MCV and body composition. Therefore, we evaluated the association between MCV levels and trunk muscle quality, muscle quantity and visceral fat area. MATERIALS AND
methodsIn our cross-sectional study, we investigated 702 middle-aged Japanese individuals without anemia and with normal MCV levels who underwent physical checkups. The cross-sectional area of skeletal muscle or visceral fat was analyzed by computed tomography.
resultsIn the adjusted model, the MCV was independently associated with the visceral fat area index (β = -0.107, P = 0.0007), total skeletal muscle index (β = 0.053, P = 0.0341) and total skeletal muscle density (β = 0.099, P = 0.0012). MCV as a continuous variable was related to the prevalence of sarcopenia (odds ratios [OR] 0.93, 95% confidence intervals (CI) 0.88-0.98, per 1.0 fL increment; P = 0.0097) and visceral obesity (OR 0.91, 95% CI 0.86-0.97, per 1.0 fL increment; P = 0.0046). The highest MCV quartile was independently associated with the prevalence of sarcopenia (OR 0.48, 95% CI 0.27-0.83; P = 0.0089) and visceral obesity (OR 0.49, 95% CI 0.27-0.88; P = 0.0170), compared with the lowest quartile.
conclusionsIn individuals without anemia and with normal MCV levels, a lower MCV was associated with unfavorable body composition, including lower muscle quality, lower muscle quantity, sarcopenia and visceral obesity.
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