ArticleMolecular systems biology2020
Dormancy-to-death transition in yeast spores occurs due to gradual loss of gene-expressing ability.
Article in Molecular systems biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Review
- Dry versus wet dormancy: suspended lives ofmSystems · 2026Review
- Matters of life and death in computational cell biology.NPJ systems biology and applications · 2026Review
- Discreteness, Computation, and Rules of Life for Self-Organization Dynamics Beyond Equilibrium.Newton ((New York, N.Y.) · 2026Article
- MFS-transporter Flr1 is a major drug-efflux transporter in Saccharomyces cerevisiae ascospores.FEMS yeast research · 2026Article
- Gradients of Aliveness and Engineering: A Taxonomy of Fungal Engineered Living Materials.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Article
- Molecular and Biophysical Perspectives on Dormancy Breaking: Lessons from Yeast Spore.Biomolecules · 2025Review
- Roles for the canonical polarity machinery in the de novo establishment of polarity in budding yeast spores.Molecular biology of the cell · 2025Article
- Wild yeast isolation by middle-school students reveals features of populations residing on North American oaks.G3 (Bethesda, Md.) · 2025Article
- Roles for the canonical polarity machinery in thebioRxiv : the preprint server for biology · 2025Article
- Inertial effect of cell state velocity on the quiescence-proliferation fate decision.NPJ systems biology and applications · 2024Article
- Wild yeast isolation by middle school students reveals features of North American oak populations ofbioRxiv : the preprint server for biology · 2024Article
- Microbial life in slow and stopped lanes.Trends in microbiology · 2024Review
- Sporulation: A response to starvation in the fission yeast Schizosaccharomyces pombe.MicrobiologyOpen · 2022Review
- Dormancy-to-death transition in yeast spores occurs due to gradual loss of gene-expressing ability.Molecular systems biology · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dormancy is colloquially considered as extending lifespan by being still. Starved yeasts form dormant spores that wake-up (germinate) when nutrients reappear but cannot germinate (die) after some time. What sets their lifespans and how they age are open questions because what processes occur-and by how much-within each dormant spore remains unclear. With single-cell-level measurements, we discovered how dormant yeast spores age and die: spores have a quantifiable gene-expressing ability during dormancy that decreases over days to months until it vanishes, causing death. Specifically, each spore has a different probability of germinating that decreases because its ability to-without nutrients-express genes decreases, as revealed by a synthetic circuit that forces GFP expression during dormancy. Decreasing amounts of molecules required for gene expression-including RNA polymerases-decreases gene-expressing ability which then decreases chances of germinating. Spores gradually lose these molecules because they are produced too slowly compared with their degradations, causing gene-expressing ability to eventually vanish and, thus, death. Our work provides a systems-level view of dormancy-to-death transition.
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