Evidence map›Paper›PMID 33206421›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021

In Vitro and In Vivo Sequestration of Phencyclidine by Me

Steven Murkli, Jared Klemm, Adam T Brockett, Michael Shuster, Volker Briken, Matthew R Roesch, Lyle Isaacs

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. An overview of the SAMPL8 host-guest binding challenge.Journal of computer-aided molecular design · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Steven MurkliDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.ORCID http://orcid.org/0000-0003-1563-0139
Jared KlemmDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.
Adam T BrockettDepartment of Psychology, University of Maryland, College Park, MD, 20742, USA.ORCID http://orcid.org/0000-0001-7712-5053
Michael ShusterDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.
Volker BrikenDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, 20742, USA.ORCID http://orcid.org/0000-0001-5830-6107
Matthew R RoeschDepartment of Psychology, University of Maryland, College Park, MD, 20742, USA.ORCID http://orcid.org/0000-0003-2854-6593
Lyle IsaacsDepartment of Chemistry and Biochemistry, University of Maryland, College Park, MD, 20742, USA.ORCID http://orcid.org/0000-0002-4079-332X

Funding

Training in Host-pathogens interactionsT32AI089621 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI LEE, VINCENT T, MCIVER, KEVIN S. · 2010 to 2025
$2.1M
Acyclic Cucurbit n uril Molecular Containers for Drug Solubilization and DeliveryR01CA168365 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI BRIKEN, VOLKER, ISAACS, LYLE D · 2013 to 2017
$1.9M
Helium Recovery System for University of MarylandR01GM132345 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI ISAACS, LYLE D · 2019 to 2022
$1.9M
Training Program in Cell & Molecular BiologyT32GM080201 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DELWICHE, CHARLES F · 2009 to 2019
$1.6M
National Science Foundation CHE-1404911NCI NIH HHS CA168365NCI NIH HHS R01 CA168365NIAID NIH HHS T32 AI089621NIGMS NIH HHS GM132345NIGMS NIH HHS R01 GM132345NIGMS NIH HHS T32 GM080201Office of Postsecondary Education P200A150033
6 · The paper itself

Abstract

We report investigations of the use of cucurbit[8]uril (CB[8]) macrocycles as an antidote to counteract the in vivo biological effects of phencyclidine. We investigate the binding of CB[8] and its derivative Me

Indexed as

AnimalsBridged-Ring CompoundsCucurbit(n)urilsHEK293 CellsHep G2 CellsHumansImidazolesLocomotionMacrocyclic CompoundsMicePhencyclidineBridged-Ring Compoundscucurbit(8)urilCucurbit(n)urilsImidazolesMacrocyclic CompoundsPhencyclidinecucurbiturilhyperlocomotionmolecular recognitionphencyclidinesequestration agents

Identifiers

PMID33206421
PMCPMC7902406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.