ArticleInternational urology and nephrology2021
Proton-pump inhibitors associated with decreased urinary citrate excretion.
Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Genetic causal association between kidney stones and proton pump inhibitors.International urology and nephrology · 2026Article
- Proton pump inhibitors and the risk of urolithiasis: A Mendelian randomization study.Medicine · 2025Article
- Proton pump inhibitors use is associated with a higher prevalence of kidney stones: NHANES 2007-2018.BMC public health · 2024Article
- Article
- Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study.Journal of clinical medicine · 2022Article
- Proton pump inhibitors use and risk of incident nephrolithiasis.Urolithiasis · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionProton-pump inhibitors (PPIs) may increase the risk of kidney stone formation, but the mechanism has not been elucidated. There is a paucity of literature evaluating the effects of PPIs on urinary metabolites and urine pH.
methodsWe performed a retrospective review of nephrolithiasis patients treated at our institution and compared patients who were taking PPIs to those who were not at the time of their 24-h urine collections. Hierarchical multivariate linear regression was used to evaluate the independent relationship between PPI use and urinary mineral composition.
resultsWe identified 301 consecutive patients, 88 (29%) of whom were taking PPIs at the time of their 24-h urine collections. Patients taking PPIs were older and more likely to have medical comorbidities associated with metabolic syndrome such as hypertension, diabetes, and dyslipidemia (p < 0.01). Controlling for these factors, patients taking PPIs were found to have 12% lower 24-h urine citrate excretion (β = - 0.12, ΔF = 4.24, p = 0.04). There were no other differences in urinary mineral composition between the groups.
conclusionOur findings suggest that patients who take PPIs regularly may be at risk for decreased urinary citrate excretion. The consequent decrease in urinary citrate may become clinically significant for patients with other predisposing factors for hypocitraturia.
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