Evidence map›Paper›PMID 33206316›Full record

ArticleNeurochemical research2021

Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice.

Magdalena Drabik, Mariusz Głuszak, Paula Wróblewska-Łuczka, Zbigniew Plewa, Marek Jankiewicz, Justyna Kozińska, Magdalena Florek-Łuszczki, Tomasz Plech, Jarogniew J Łuszczki

Open access · hybridAbstract read
In one paragraph

Article in Neurochemical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Magdalena DrabikDepartment of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, PL 20-090, Lublin, Poland.ORCID https://orcid.org/0000-0003-4424-4915
Mariusz GłuszakDepartment of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, PL 20-090, Lublin, Poland.
Paula Wróblewska-ŁuczkaDepartment of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, PL 20-090, Lublin, Poland.ORCID https://orcid.org/0000-0002-7099-1968
Zbigniew PlewaDepartment of General, Oncological, and Minimally Invasive Surgery, 1 Military Clinical Hospital with the Outpatient Clinic in Lublin, Lublin, Poland.ORCID https://orcid.org/0000-0001-6255-5085
Marek JankiewiczDepartment and Clinic of Cardiology, Medical University of Lublin, Lublin, Poland.ORCID https://orcid.org/0000-0001-9900-9168
Justyna KozińskaDepartment and Clinic of Hematolooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland.ORCID https://orcid.org/0000-0001-8817-5638
Magdalena Florek-ŁuszczkiDepartment of Medical Anthropology, Institute of Rural Health, Lublin, Poland.ORCID https://orcid.org/0000-0003-1489-2399
Tomasz PlechDepartment of Pharmacology, Medical University of Lublin, Lublin, Poland.ORCID https://orcid.org/0000-0002-8162-8435
Jarogniew J ŁuszczkiDepartment of Pathophysiology, Medical University of Lublin, Jaczewskiego 8b, PL 20-090, Lublin, Poland. jluszczki@yahoo.com.ORCID https://orcid.org/0000-0002-3059-0393
Medical University of Lublin · PL1 Military Clinical Hospital with Outpatient Clinic · PLInstytut Medycyny Wsi im. Witolda Chodźki · PL

Funding

Narodowe Centrum Nauki UMO-2013/11/D/NZ7/01170
6 · The paper itself

Abstract

Protective (antiseizure) effects of 4-butyl-5-[(4-chloro-2-methylphenoxy)-methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) and acute neurotoxic effects were determined in the tonic-clonic seizure model and rotarod test in mice. The interaction profile of four classic antiepileptic drugs (carbamazepine, phenobarbital, phenytoin and valproate) with TPL-16 was also determined in the tonic-clonic seizure model in mice. The protective effects of TPL-16 from tonic-clonic seizures (as ED

Indexed as

AnimalsAnticonvulsantsCarbamazepineDrug SynergismMaleMiceMuscle StrengthPhenobarbitalPhenytoinRotarod Performance TestSeizuresThionesTriazolesValproic AcidAnticonvulsantsCarbamazepinePhenobarbitalPhenytoinThionesTriazolesValproic Acid1,2,4-triazole-3-thioneAntiepileptic drugsPharmacokinetic/pharmacodynamic interactionProtective indexTonic-clonic seizures

Identifiers

PMID33206316
PMCPMC7854423
OpenAlexW3098373555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.