Evidence map›Paper›PMID 33206301›Full record

ArticleLa Radiologia medica2021

COVID-19 pneumonia: computer-aided quantification of healthy lung parenchyma, emphysema, ground glass and consolidation on chest computed tomography (CT).

Roberto Grassi, Maria Paola Belfiore, Alessandro Montanelli, Gianluigi Patelli, Fabrizio Urraro, Giuliana Giacobbe, Roberta Fusco, Vincenza Granata, Antonella Petrillo, Palmino Sacco and 4 more

Abstract read
In one paragraph

Article in La Radiologia medica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

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  6. Artificial intelligence algorithms based approach in evaluating COVID-19 patients and management.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025
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  18. Exploring Radiologists' Burnout in the COVID-19 Era: A Narrative Review.International journal of environmental research and public health · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Roberto GrassiDivision of Radiodiagnostic, Università Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy. roberto.grassi@unicampania.it.
Maria Paola BelfioreDivision of Radiodiagnostic, Università Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy.
Alessandro MontanelliLaboratory Medicine Unit, ASST Bergamo Est, Seriate, Italy.
Gianluigi PatelliDepartment of Radiology, ASST Bergamo Est, Seriate, Italy.
Fabrizio UrraroDivision of Radiodiagnostic, Università Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy.
Giuliana GiacobbeDivision of Radiodiagnostic, Università Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy.
Roberta FuscoRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale - IRCCS di Napoli, Naples, Italy.
Vincenza GranataRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale - IRCCS di Napoli, Naples, Italy.
Antonella PetrilloRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale - IRCCS di Napoli, Naples, Italy.
Palmino SaccoDepartment of Radiological Sciences, Diagnostic Imaging Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Maria Antonietta MazzeiDepartment of Radiological Sciences, Diagnostic Imaging Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
Beatrice FeragalliDepartment of Medical, Oral and Biotechnological Sciences -Radiology Unit "G. D'Annunzio", University of Chieti-Pescara, Chieti, Italy.
Alfonso ReginelliDivision of Radiodiagnostic, Università Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy.
Salvatore CappabiancaDivision of Radiodiagnostic, Università Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo calculate by means of a computer-aided tool the volumes of healthy residual lung parenchyma, of emphysema, of ground glass opacity (GGO) and of consolidation on chest computed tomography (CT) in patients with suspected viral pneumonia by COVID-19. MATERIALS AND

methodsThis study included 116 patients that for suspected COVID-19 infection were subjected to the reverse transcription real-time fluorescence polymerase chain reaction (RT-PCR) test. A computer-aided tool was used to calculate on chest CT images healthy residual lung parenchyma, emphysema, GGO and consolidation volumes for both right and left lung. Expert radiologists, in consensus, assessed the CT images using a structured report and attributed a radiological severity score at the disease pulmonary involvement using a scale of five levels. Nonparametric test was performed to assess differences statistically significant among groups.

resultsGGO was the most represented feature in suspected CT by COVID-19 infection; it is present in 102/109 (93.6%) patients with a volume percentage value of 19.50% and a median value of 0.64 L, while the emphysema and consolidation volumes were low (0.01 L and 0.03 L, respectively). Among quantified volume, only GGO volume had a difference statistically significant between the group of patients with suspected versus non-suspected CT for COVID-19 (p < < 0.01). There were differences statistically significant among the groups based on radiological severity score in terms of healthy residual parenchyma volume, of GGO volume and of consolidations volume (p < < 0.001).

conclusionWe demonstrated that, using a computer-aided tool, the COVID-19 pneumonia was mirrored with a percentage median value of GGO of 19.50% and that only GGO volume had a difference significant between the patients with suspected or non-suspected CT for COVID-19 infection.

Indexed as

Radiographic Image Interpretation, Computer-AssistedTomography, X-Ray ComputedAdultAgedAged, 80 and overCOVID-19COVID-19 Nucleic Acid TestingFemaleHumansLungMaleMiddle AgedPulmonary EmphysemaSARS-CoV-2SoftwareComputer toolCOVID-19TomographyVolume quantificationX-ray computed

Identifiers

PMID33206301
PMCPMC7673247

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.