Evidence map›Paper›PMID 33206093›Full record

ReviewNatural product reports2021

Building

Wanli Zhang, Anna R Kaplan, Emma K Davison, Jared L Freeman, Margaret A Brimble, William M Wuest

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Natural product reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wanli ZhangDepartment of Chemistry, Emory University, USA. wwuest@emory.edu.
Anna R KaplanDepartment of Chemistry, Emory University, USA. wwuest@emory.edu.
Emma K DavisonSchool of Chemical Sciences, University of Auckland, 23 Symonds St., Auckland, 1010, New Zealand and School of Biological Sciences, University of Auckland, 23 Symonds St., Auckland, 1010, New Zealand and The Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.ORCID 0000-0002-9280-2742
Jared L FreemanSchool of Chemical Sciences, University of Auckland, 23 Symonds St., Auckland, 1010, New Zealand and The Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.ORCID 0000-0002-5448-5010
Margaret A BrimbleSchool of Chemical Sciences, University of Auckland, 23 Symonds St., Auckland, 1010, New Zealand and School of Biological Sciences, University of Auckland, 23 Symonds St., Auckland, 1010, New Zealand and The Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.ORCID 0000-0002-7086-4096
William M WuestDepartment of Chemistry, Emory University, USA. wwuest@emory.edu and Emory Antibiotic Resistance Center, Emory School of Medicine, USA.ORCID 0000-0002-5198-7744

Funding

Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific InhibitorsR35GM119426 · NIGMS · TEMPLE UNIV OF THE COMMONWEALTH · PI William M Wuest · 2016 to 2026
$4.8M
NIGMS NIH HHS R35 GM119426
6 · The paper itself

Abstract

Covering: 2000 to 2020. trans-Bicyclo[4.4.0]decane/decene (such as trans-decalin and trans-octalin)-containing natural products display a wide range of structural diversity and frequently exhibit potent and selective antibacterial activities. With one of the major factors in combatting antibiotic resistance being the discovery of novel scaffolds, the efficient construction of these natural products is an attractive pursuit in the development of novel antibiotics. This highlight aims to provide a critical analysis on how the presence of dense architectural and stereochemical complexity necessitated special strategies in the synthetic pursuits of these natural trans-bicyclo[4.4.0]decane/decene antibiotics.

Indexed as

AlkanesAnti-Bacterial AgentsBiological ProductsBridged Bicyclo CompoundsMolecular StructureAlkanesAnti-Bacterial AgentsBiological ProductsBridged Bicyclo Compoundsdecane

Identifiers

PMID33206093
PMCPMC8322967

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.