Evidence map›Paper›PMID 33205945›Full record

ArticleBiochemistry2020

The RNA Polymerase α Subunit Recognizes the DNA Shape of the Upstream Promoter Element.

Samuel Lara-Gonzalez, Ana Carolina Dantas Machado, Satyanarayan Rao, Andrew A Napoli, Jens Birktoft, Rosa Di Felice, Remo Rohs, Catherine L Lawson

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  9. Genome-wide promoter assembly inGenome research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Samuel Lara-GonzalezDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-3313-0165
Ana Carolina Dantas MachadoQuantitative and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States.
Satyanarayan RaoQuantitative and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States.ORCID 0000-0001-7678-3505
Andrew A NapoliDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, United States.
Jens BirktoftDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, United States.
Rosa Di FeliceQuantitative and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States.ORCID 0000-0002-7772-6550
Remo RohsQuantitative and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, United States.ORCID 0000-0003-1752-1884
Catherine L LawsonDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, United States.ORCID 0000-0002-3261-7035
Rutgers, The State University of New Jersey · USUniversity of Southern California · US

Funding

Quantitative Modeling of Transcription Factor-DNA BindingR35GM130376 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Remo Rohs · 2019 to 2026
$3.3M
NUCLEIC ACID STRUCTURES AND INTERACTIONSR01GM021589 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI LAWSON, CATHERINE L · 1985 to 2009
$2.7M
Genome analysis based on the integration of DNA sequence and shapeR01GM106056 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROHS, REMO · 2014 to 2017
$1.3M
NIGMS NIH HHS R01 GM021589NIGMS NIH HHS R01 GM106056NIGMS NIH HHS R35 GM130376
6 · The paper itself

Abstract

We demonstrate here that the α subunit C-terminal domain of

Indexed as

Binding SitesCrystallography, X-RayCyclic AMP Receptor ProteinDNA, BacterialDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsGene Knockout TechniquesGenes, BacterialModels, MolecularMutationNucleic Acid ConformationPromoter Regions, GeneticProtein DomainsStatic ElectricityCyclic AMP Receptor ProteinDNA, BacterialDNA-Directed RNA PolymerasesEscherichia coli ProteinsRNA polymerase alpha subunit

Identifiers

PMID33205945
PMCPMC8100869
OpenAlexW3102018710

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.