Evidence map›Paper›PMID 33205895›Full record

ArticleBrain and behavior2021

Impact of non-CNS childhood cancer on resting-state connectivity and its association with cognition.

Janine S Spitzhüttl, Martin Kronbichler, Lisa Kronbichler, Valentin Benzing, Valerie Siegwart, Manuela Pastore-Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Claudia M Roebers and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06312969 (Cognitive Training Through Technological Gaming To Ameliorate Cognitive Effects Related To Childhood Cancer Treatment), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06312969 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Cognitive Training Through Technological Gaming To Ameliorate Cognitive Effects Related To Childhood Cancer Treatment (WINNERS)

TypeinterventionalSponsorAntonio Pérez MartínezRan2023 to 2025Enrolled56ConditionsSurvivors of Childhood CancerArmsVideo game based training
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Janine S SpitzhüttlDepartment of Psychology, University of Bern, Bern, Switzerland.
Martin KronbichlerCentre for Cognitive Neuroscience and Department of Psychology, University of Salzburg, Salzburg, Austria.
Lisa KronbichlerCentre for Cognitive Neuroscience and Department of Psychology, University of Salzburg, Salzburg, Austria.
Valentin BenzingDepartment of Pediatric Hematology and Oncology, University Children's Hospital Bern, University of Bern, Bern, Switzerland.
Valerie SiegwartNeuropediatrics, Development and Rehabilitation, University Children's Hospital Bern, and University of Bern, Bern, Switzerland.
Manuela Pastore-WappSupport Center for Advanced Neuroimaging (SCAN), Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Claus KieferSupport Center for Advanced Neuroimaging (SCAN), Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Nedelina SlavovaSupport Center for Advanced Neuroimaging (SCAN), Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.
Michael GrotzerDepartment of Pediatric Oncology, University Children's Hospital Zurich, Zurich, Switzerland.
Claudia M RoebersDepartment of Psychology, University of Bern, Bern, Switzerland.
Maja SteinlinNeuropediatrics, Development and Rehabilitation, University Children's Hospital Bern, and University of Bern, Bern, Switzerland.
Kurt LeibundgutDepartment of Pediatric Hematology and Oncology, University Children's Hospital Bern, University of Bern, Bern, Switzerland.
Regula EvertsNeuropediatrics, Development and Rehabilitation, University Children's Hospital Bern, and University of Bern, Bern, Switzerland.ORCID 0000-0001-6556-3419
University of Bern · CHUniversity of Salzburg · ATUniversity Children's Hospital Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNon-central nervous system cancer in childhood (non-CNS CC) and its treatments pose a major threat to brain development, with implications for functional networks. Structural and functional alterations might underlie the cognitive late-effects identified in survivors of non-CNS CC. The present study evaluated resting-state functional networks and their associations with cognition in a mixed sample of non-CNS CC survivors (i.e., leukemia, lymphoma, and other non-CNS solid tumors).

methodsForty-three patients (off-therapy for at least 1 year and aged 7-16 years) were compared with 43 healthy controls matched for age and sex. High-resolution T1-weighted structural magnetic resonance and resting-state functional magnetic resonance imaging were acquired. Executive functions, attention, processing speed, and memory were assessed outside the scanner.

resultsCognitive performance was within the normal range for both groups; however, patients after CNS-directed therapy showed lower executive functions than controls. Seed-based connectivity analyses revealed that patients exhibited stronger functional connectivity between fronto- and temporo-parietal pathways and weaker connectivity between parietal-cerebellar and temporal-occipital pathways in the right hemisphere than controls. Functional hyperconnectivity was related to weaker memory performance in the patients' group.

conclusionThese data suggest that even in the absence of brain tumors, non-CNS CC and its treatment can lead to persistent cerebral alterations in resting-state network connectivity.

Indexed as

NeoplasmsBrainBrain MappingChildCognitionExecutive FunctionHumansMagnetic Resonance ImagingNeural Pathwayschildhood cancer survivorscognitive late-effectsnon-CNS childhood cancersresting-state networksrs-fMRI analysis

Identifiers

PMID33205895
PMCPMC7821559
OpenAlexW3099355238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.