Evidence map›Paper›PMID 33205892›Full record

Observational studyPediatric pulmonology2021

Performance of lung ultrasound in the diagnosis of pediatric pneumonia in Mozambique and Pakistan.

Amy Sarah Ginsburg, Jennifer L Lenahan, Fyezah Jehan, Rubao Bila, Alessandro Lamorte, Jun Hwang, Lola Madrid, Muhammad Imran Nisar, Pio Vitorino, Neel Kanth and 8 more

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Pediatric pulmonology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Observational
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 5 countries.

Amy Sarah GinsburgClinical Trial Center, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-2291-2276
Jennifer L LenahanSave the Children Federation, Inc., Seattle, Washington, USA.
Fyezah JehanDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Rubao BilaCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Alessandro LamorteDepartment of Emergency Medicine, Parini Hospital, Aosta, Italy.
Jun HwangClinical Trial Center, University of Washington, Seattle, Washington, USA.
Lola MadridISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
Muhammad Imran NisarDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Pio VitorinoCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Neel KanthSindh Government Children's Hospital-Poverty Eradication Initiative, Karachi, Pakistan.
Reyes BalcellsISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
Benazir BalochDepartment of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Susanne MayClinical Trial Center, University of Washington, Seattle, Washington, USA.
Marta ValenteISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
Rosauro VaroISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain.
Naila NadeemDepartment of Radiology, Aga Khan University, Karachi, Pakistan.
Quique BassatCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.ORCID 0000-0003-0875-7596
Giovanni VolpicelliDepartment of Emergency Medicine, San Luigi Gonzaga University Hospital, Orbassano, Italy.
Aga Khan University · PKBarcelona Institute for Global Health · ESUniversity of Washington · USManhiça Health Research Centre · MZDe Agostini (Italy) · ITGovernment of Pakistan · PKInstitució Catalana de Recerca i Estudis Avançats · ESOspedale San Luigi Gonzaga · ITSave the Children · US

Funding

Gates Foundation OPP1105080Medical Research Council MR/L004283/1
6 · The paper itself

Abstract

introductionImproved pneumonia diagnostics are needed in low-resource settings (LRS); lung ultrasound (LUS) is a promising diagnostic technology for pneumonia. The objective was to compare LUS versus chest radiograph (CXR), and among LUS interpreters, to compare expert versus limited training with respect to interrater reliability.

methodsWe conducted a prospective, observational study among children with World Health Organization (WHO) Integrated Management of Childhood Illness (IMCI) chest-indrawing pneumonia at two district hospitals in Mozambique and Pakistan, and assessed LUS and CXR examinations. The primary endpoint was interrater reliability between LUS and CXR interpreters for pneumonia diagnosis among children with WHO IMCI chest-indrawing pneumonia.

resultsInterrater reliability was excellent for expert LUS interpreters, but poor to moderate for expert CXR interpreters and onsite LUS interpreters with limited training.

conclusionsAmong children with WHO IMCI chest-indrawing pneumonia, expert interpreters may achieve substantially higher interrater reliability for LUS compared to CXR, and LUS showed potential as a preferred reference standard. For point-of-care LUS to be successfully implemented for the diagnosis and management of pneumonia in LRS, the clinical environment and amount of appropriate user training will need to be understood and addressed.

Indexed as

FemaleHumansInfantLungMaleMozambiquePakistanPneumoniaRadiography, ThoracicReproducibility of ResultsUltrasonographychest ultrasoundchildhood pneumoniainterrater reliabilitylow-resource settings

Identifiers

PMID33205892
PMCPMC7898329
OpenAlexW3103659985

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.