ArticleeLife2020
Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Dopamine and the dynamics of subthalamic and leg muscle activities in parkinsonian stepping.Brain : a journal of neurology · 2026Article
- Characterising motor and cognitive contributions of cortical beta oscillations and their modulation with rTMS.NeuroImage · 2026Article
- Cortical beta coherence provides a stronger non-invasive predictor of movement vigor than local beta power.Journal of neuroengineering and rehabilitation · 2026Article
- Low-frequency activity in the subthalamic nucleus informs about the acute neuropsychiatric state in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Lower limb motor effects of DBS neurofeedback in Parkinson's disease assessed through IMU-based UPDRS movement quality metrics.Scientific reports · 2025Article
- Beta bursts mediate amygdala gating of hippocampal emotional encoding.bioRxiv : the preprint server for biology · 2025Article
- Opportunities and challenges for deep brain stimulation electrode-guided neurofeedback for symptom mitigation in neurological and psychiatric disorders.Journal of neuroengineering and rehabilitation · 2025Review
- Changes in cortical beta power predict motor control flexibility, not vigor.Communications biology · 2025Article
- Volitional Regulation and Transferable Patterns of Midbrain Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Factors affecting targeting accuracy in minimally invasive twist drill deep brain stimulation.Surgical neurology international · 2025Article
- Motor actions across psychiatric disorders: A research domain criteria (RDoC) perspective.Clinical psychology review · 2024Review
- Comparison of beta peak detection algorithms for data-driven deep brain stimulation programming strategies in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Exploring the Feasibility of Bidirectional Control of Beta Oscillatory Power in Healthy Controls as a Potential Intervention for Parkinson's Disease Movement Impairment.Sensors (Basel, Switzerland) · 2024Article
- Cross-frequency cortex-muscle interactions are abnormal in young people with dystonia.Brain communications · 2024Article
- Beta-triggered adaptive deep brain stimulation during reaching movement in Parkinson's disease.Brain : a journal of neurology · 2023Article
- Tuned to Tremor: Increased Sensitivity of Cortico-Basal Ganglia Neurons to Tremor Frequency in the MPTP Nonhuman Primate Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Clinical neurophysiological interrogation of motor slowing: A critical step towards tuning adaptive deep brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Progress in the development of a fully implantable brain-computer interface: the potential of sensing-enabled neurostimulators.National science review · 2022Article
- Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings.NPJ Parkinson's disease · 2022Article
- Subthalamic-Cortical Network Reorganization during Parkinson's Tremor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Previous studies have explored neurofeedback training for Parkinsonian patients to suppress beta oscillations in the subthalamic nucleus (STN). However, its impacts on movements and Parkinsonian tremor are unclear. We developed a neurofeedback paradigm targeting STN beta bursts and investigated whether neurofeedback training could improve motor initiation in Parkinson's disease compared to passive observation. Our task additionally allowed us to test which endogenous changes in oscillatory STN activities are associated with trial-to-trial motor performance. Neurofeedback training reduced beta synchrony and increased gamma activity within the STN, and reduced beta band coupling between the STN and motor cortex. These changes were accompanied by reduced reaction times in subsequently cued movements. However, in Parkinsonian patients with pre-existing symptoms of tremor, successful volitional beta suppression was associated with an amplification of tremor which correlated with theta band activity in STN local field potentials, suggesting an additional cross-frequency interaction between STN beta and theta activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.