ArticleCirculation2021
Central Command and the Regulation of Exercise Heart Rate Response in Heart Failure With Preserved Ejection Fraction.
Article in Circulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Peak oxygen uptake in older adults with heart failure: a systematic review and meta-analysis.GeroScience · 2026Pooled it
- Neurocardiology: Brain-Heart Interactions in the Heart.MedComm · 2026Review
- Impact of inspiratory muscle training on inspiratory muscle metaboreflex in patients with heart failure with preserved ejection fraction.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Exploring The Physiological and Physical Basis of RPE Responses in Soccer: A Comparative Analysis of Internal and External Load Determinants Across Different Training Drills.Journal of sports science & medicine · 2025Article
- Impaired exercise hemodynamic responses in patients with HFpEF without a sympathetic vasoconstrictor reserve.Autonomic neuroscience : basic & clinical · 2025Article
- Maintained sympathetic reactivity but blunted pressor response to static handgrip exercise in heart failure with preserved ejection fraction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Dissecting the exercise pressor reflex in heart failure: A multi-step failure.Autonomic neuroscience : basic & clinical · 2025Review
- Determinants of cardiac output in health and heart failure.Experimental physiology · 2025Review
- Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole.Antioxidants (Basel, Switzerland) · 2024Review
- β-blockers may be detrimental in frail patients with heart failure with preserved ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Observational
- Ambulatory Monitoring of Cerebrovascular Responses to Upright Posture and Walking in Older Adults With Heart Failure.CJC open · 2023Article
- Neural control of the circulation during exercise in heart failure with reduced and preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2023Review
- Cardiovascular responses to static handgrip exercise and postexercise ischemia in heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Sympathetic and hemodynamic responses to exercise in heart failure with preserved ejection fraction.Frontiers in cardiovascular medicine · 2023Review
- Inspiratory and leg muscle blood flows during inspiratory muscle metaboreflex activation in heart failure with preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Exercise testing in heart failure with preserved ejection fraction: an appraisal through diagnosis, pathophysiology and therapy - A clinical consensus statement of the Heart Failure Association and European Association of Preventive Cardiology of the European Society of Cardiology.European journal of heart failure · 2022Article
- Heart Failure with Preserved Ejection Fraction: Mechanisms and Treatment Strategies.Annual review of medicine · 2022Review
- Skeletal muscle phenotypic switching in heart failure with preserved ejection fraction.Frontiers in cardiovascular medicine · 2022Article
- Comparison of haemodynamic response to muscle reflex in heart failure with reduced vs. preserved ejection fraction.ESC heart failure · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundChronotropic incompetence is common in heart failure with preserved ejection fraction (HFpEF) and is linked to impaired aerobic capacity. Whether upstream autonomic signaling pathways responsible for raising exercise heart rate are impaired in HFpEF is unknown. We investigated the integrity of central command and muscle metaboreceptor function, 2 predominant mechanisms responsible for exertional increases in heart rate, in patients with HFpEF and senior controls.
methodsFourteen healthy senior controls (7 men, 7 women) and 20 carefully screened patients with HFpEF (8 men, 12 women) underwent cardiopulmonary exercise testing (peak Vo
resultsPeak Vo
conclusionsCentral command (vagally mediated) and metaboreceptor function (sympathetically mediated) in patients with HFpEF were not different from those in healthy senior controls despite significantly lower peak whole-body exercise heart rates. These results demonstrate key reflex autonomic pathways regulating exercise heart rate responsiveness are intact in HFpEF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.