ArticleJournal of biomedical optics2020
Anthropomorphic optical phantom of the neonatal thorax: a key tool for pulmonary studies in preterm infants.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
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- Influence of the orientation of constructed blood vessels during the 3D printing on the measurement of the pseudo-oxygen saturation of an artificial blood substitute using conventional oxygen sensors: a test series.3D printing in medicine · 2024Article
- Initial non-invasive in vivo sensing of the lung using time domain diffuse optics.Scientific reports · 2024Article
- Hybrid heterogeneous phantoms for biomedical applications: a demonstration to dosimetry validation.Biomedical optics express · 2024Article
- Laser absorption spectroscopy measurements of different pulmonary oxygen gas concentrations in transmittance and remittance geometry: phantom study.Journal of biomedical optics · 2023Article
- Two-layered blood-lipid phantom and method to determine absorption and oxygenation employing changes in moments of DTOFs.Biomedical optics express · 2023Article
- Solid optical tissue phantom tools based on upconverting nanoparticles for biomedical applications.Journal of biomedical optics · 2023Article
- Gas in scattering media absorption spectroscopy as a potential tool in neonatal respiratory care.Pediatric research · 2022Review
- Lung tissue phantom mimicking pulmonary optical properties, relative humidity, and temperature: a tool to analyze the changes in oxygen gas absorption for different inflated volumes.Journal of biomedical optics · 2021Article
- 3D Printing of Physical Organ Models: Recent Developments and Challenges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Anatase Titanium Dioxide Imparts Photoluminescent Properties to PA2200 Commercial 3D Printing Material to Generate Complex Optical Imaging Phantoms.Materials (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
significanceGas in scattering media absorption spectroscopy (GASMAS) is a technique for gas sensing in cavities surrounded by scattering materials. GASMAS could be translated to the clinic to monitor lung function continuously and noninvasively in neonates. Accurate tissue phantoms are essential to assess the strengths and limitations of gas spectroscopy in gas-containing cavities in the human body.
aimThe aim is to develop a detailed protocol to produce a long-lasting, multistructure tissue phantom of the thorax of a neonate. The phantom mimics the geometry and the optical properties of the main organs of the thorax and has an empty pulmonary cavity that facilitates GASMAS monitoring of gas content. APPROACH: The anatomic geometry of heart, lungs, bones, muscle, fat, and skin was obtained from a neonatal computed tomography scan. Once segmented, organs were 3D printed and used to create negative rubber molds. The entire thorax was built in phantom material (silicone as matrix, black ink as absorber, and silica microspheres as scatters) by placing all phantom organs inside the muscle structure. Our phantom recipe was customized by mixing specific ratios of ink and spheres to match the optical properties of the different organs that were consider to be homogeneous.
resultsAn anthropomorphic thorax phantom with the desired optical properties (μa and μs') at 760 nm was built and used to obtain "transdermal" GASMAS measurements of oxygen content within the lung cavity.
conclusionA protocol to build a robust optical phantom of the thorax of a neonate was used to conduct benchtop studies. This recipe can be implemented to reproduce the geometry and optical properties of any human or animal tissue.
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