Evidence map›Paper›PMID 33205634›Full record

ArticleJournal of biomedical optics2020

Stable fiber-based polarization-sensitive optical coherence tomography using polarization maintaining common-path interferometer.

Peijun Tang, Ruikang Wang

Open access · goldAbstract read
In one paragraph

Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Peijun TangUniv. of Washington, United States.
Ruikang WangUniv. of Washington, United States.
University of Washington · US

Funding

Perfusable 3D human cardiac constructs for heart regenerationR01HL141570 · NHLBI · UNIVERSITY OF WASHINGTON · PI MURRY, CHARLES E, ZHENG, YING · 2018 to 2021
$3.3M
NHLBI NIH HHS R01 HL141570
6 · The paper itself

Abstract

significanceOur work advances the development of fiber-based polarization-sensitive optical coherence tomography (PS-OCT) by stabilizing the output polarization state of the light beam when the system is under environmental disturbance. While the fiber-based PS-OCT has been demonstrated previously, it remains a challenge for the traditional fiber-based PS-OCT to obtain a stable measurement when the optic fibers are disturbed by the environment. This important issue is addressed, paving the path for clinical translation of PS-OCT, which can provide a unique perspective of the biological samples.

aimPolarization maintaining common-path (CP) interferometer is fabricated with the goal of providing a stable fiber-based PS-OCT imaging system that is only responsive to the polarization changes generated by the sample, immune to environmental conditions. APPROACH: The system is implemented by incorporating a CP interferometer together with polarization maintaining (PM) fibers. The PM fibers are used to preserve the two orthogonal linearly polarized components of the light during propagation. By sharing the CP in the sample and reference arms, any variations in phase retardation can be eliminated between the two channels in the PM fibers. The combination of the PM fiber and the CP interferometer ensures the stability of the output polarization state.

resultsThe stability of the proposed PS-OCT system is tested when a periodically stressed disturbance is applied to the fibers within the system. Stable in vivo PS-OCT images of the mouse thigh are demonstrated.

conclusionsWe have demonstrated a stable fiber-based PS-OCT system that combined the PM fiber and the CP configuration together. We have shown that the output polarization states and the system sensitivity can keep stable over time under the environmental disturbances to the system.

Indexed as

Fiber Optic TechnologyTomography, Optical CoherenceAnimalsMiceRefraction, Ocularbiomedical imagingoptical coherence tomographyoptics fiberpolarization

Identifiers

PMID33205634
PMCPMC7670096
OpenAlexW3099844345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.