Evidence map›Paper›PMID 33205616›Full record

ArticleMacromolecular bioscience2021

Citrate Crosslinked Poly(Glycerol Sebacate) with Tunable Elastomeric Properties.

Brandon B Risley, Xiaochu Ding, Ying Chen, Paula G Miller, Yadong Wang

Open access · greenAbstract read
In one paragraph

Article in Macromolecular bioscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Different methods of synthesizing poly(glycerol sebacate) (PGS): A review.Frontiers in bioengineering and biotechnology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Brandon B RisleyNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 277 Kimball Hall, 134 Hollister Drive, Ithaca, NY, 14853, USA.
Xiaochu DingNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 277 Kimball Hall, 134 Hollister Drive, Ithaca, NY, 14853, USA.ORCID 0000-0001-7908-7329
Ying ChenNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 277 Kimball Hall, 134 Hollister Drive, Ithaca, NY, 14853, USA.
Paula G MillerNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 277 Kimball Hall, 134 Hollister Drive, Ithaca, NY, 14853, USA.
Yadong WangNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, 277 Kimball Hall, 134 Hollister Drive, Ithaca, NY, 14853, USA.
Cornell University · USMichigan Technological University · US

Funding

Compliant and strong small arteries engineered in vitroR01HL089658 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, YADONG · 2007 to 2016
$3.4M
NHLBI NIH HHS R01 HL089658
6 · The paper itself

Abstract

Poly(glycerol-sebacate) (PGS) is a biodegradable elastomer known for its mechanical properties and biocompatibility for soft tissue engineering. However, harsh thermal crosslinking conditions are needed to make PGS devices. To facilitate the thermal crosslinking, citric acid is explored as a crosslinker to form poly(glycerol sebacate citrate) (PGSC) elastomers. The effects of varying citrate contents and curing times are investigated on the mechanical properties, elasticity, degradation, and hydrophilicity. To examine the potential presence of unreacted citric acid, material acidity is monitored in relation to the citrate content and curing times. It is discovered that a low citrate content and a short curing time produce PGSC with tunable mechanical characteristics similar to PGS with enhanced elasticity. The materials demonstrate good cytocompatibility with human umbilical vein endothelial cells similar to the PGS control. The research study suggests that PGSC is a potential candidate for large-scale biomedical applications because of the quick thermal crosslink and tunable elastomeric properties.

Indexed as

Carboxylic AcidsCell DeathCitric AcidCross-Linking ReagentsDecanoatesElastomersGlycerolHumansHuman Umbilical Vein Endothelial CellsHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsPolymersTensile StrengthWaterCarboxylic AcidsCitric AcidCross-Linking ReagentsDecanoatesElastomersGlycerolpoly(glycerol-sebacate)PolymersWaterbiomaterialcitric acidelastomerspoly(glycerol sebacate)thermal crosslinking

Identifiers

PMID33205616
PMCPMC8360362
OpenAlexW3100166842

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.