Evidence map›Paper›PMID 33205418›Full record

ArticleJournal of the American Geriatrics Society2021

Air Pollution and the Dynamic Association Between Depressive Symptoms and Memory in Oldest-Old Women.

Andrew J Petkus, Diana Younan, Xinhui Wang, Daniel P Beavers, Mark A Espeland, Margaret Gatz, Tara L Gruenewald, Joel D Kaufman, Helena C Chui, JoAnn E Manson and 5 more

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Andrew J PetkusDepartment of Neurology, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-7770-0123
Diana YounanDepartment of Preventive Medicine, University of Southern California, Los Angeles, California, USA.
Xinhui WangDepartment of Neurology, University of Southern California, Los Angeles, California, USA.
Daniel P BeaversDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-4286-9463
Mark A EspelandDepartment of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Margaret GatzCenter for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
Tara L GruenewaldDepartment of Psychology, Chapman University, Orange, California, USA.
Joel D KaufmanDepartment of Environmental & Occupational Health Sciences, University of Washington, Seattle, Washington, USA.
Helena C ChuiDepartment of Neurology, University of Southern California, Los Angeles, California, USA.
JoAnn E MansonDepartment of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Susan M ResnickThe Laboratory of Behavioral Neuroscience, National Institute on Aging, Laboratory of Behavioral Neuroscience, Bethesda, Maryland, USA.
Gregory A WelleniusDepartment of Environmental Health, Boston University, Boston, Massachusetts, USA.
Eric A WhitselDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Keith WidamanGraduate School of Education, University of California, Riverside, Riverside, California, USA.
Jiu-Chiuan ChenDepartment of Neurology, University of Southern California, Los Angeles, California, USA.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI ALI SHOJAIE · 1995 to 2026
$42.5M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
The Aging Brain: Vasculature, Ischemia, and BehaviorP01AG012435 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WEINER, MICHAEL W · 1994 to 2012
$26.4M
Wake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAPP, STEPHEN R · 2016 to 2020
$12.2M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5M
Alzheimer's Disease & Related Dementias: Geography, Environments, and MechanismsRF1AG054068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2016 to 2016
$4.1M
Environmental Determinants of Pathological Brain Aging in WHI Memory StudiesR01ES025888 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, KAUFMAN, JOEL DANIEL · 2016 to 2020
$3.2M
Environmental Determinants of Cognitive Aging in the WHI Memory StudyR01AG033078 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2011 to 2014
$2.6M
Women's Health Initiative Suite of Studies - Extension StudyZIAAG000190 · NIA · NATIONAL INSTITUTE ON AGING · PI RESNICK, SUSAN · 2009 to 2024
$1.5M
EPA RD831697EPA RD-83830001NHLBI NIH HHS HHSN268201100001CNHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002CNHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003CNHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004CNHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046cNHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN271201100004CNIA NIH HHS HHSN271201100004CNIA NIH HHS N01-AG-1-2106NIA NIH HHS P01 AG012435NIA NIH HHS P01 AG055367NIA NIH HHS P01AG055367NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG066530NIA NIH HHS P50 AG005142NIA NIH HHS P50AG005142NIA NIH HHS R01 AG033078NIA NIH HHS R01AG033078NIA NIH HHS RF1 AG054068NIA NIH HHS RF1AG054068NIEHS NIH HHS 5P30ES007048NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES025888NIEHS NIH HHS R01ES025888WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

BACKGROUND/

objectivesExposure to air pollution may contribute to both increasing depressive symptoms and decreasing episodic memory in older adulthood, but few studies have examined this hypothesis in a longitudinal context. Accordingly, we examined the association between air pollution and changes in depressive symptoms (DS) and episodic memory (EM) and their interrelationship in oldest-old (aged 80 and older) women.

designProspective cohort data from the Women's Health Initiative Memory Study-Epidemiology of Cognitive Health Outcomes.

settingGeographically diverse community-dwelling population.

participantsA total of 1,583 dementia-free women aged 80 and older. MEASUREMENTS: Women completed up to six annual memory assessments (latent composite of East Boston Memory Test and Telephone Interview for Cognitive Status) and the 15-item Geriatric Depression Scale (GDS-15). We estimated 3-year average exposures to regional particulate matter with aerodynamic diameter below 2.5 μm (PM

resultsLatent change structural equation models examined whether residing in areas with higher pollutant levels was associated with annual changes in standardized EM and DS while adjusting for potential confounders. Remote NO

conclusionThese findings in oldest-old women point to potential adverse effects of late-life exposure to air pollution on subsequent interplay between DS and EM, highlighting air pollution as an environmental health risk factor for older women.

Indexed as

Air PollutionDepressionEnvironmental ExposureMemory DisordersMemory, EpisodicAged, 80 and overCognitionFemaleGeriatric AssessmentHumansIndependent LivingMental Status ScheduleParticulate MatterRisk AssessmentRisk FactorsUnited StatesParticulate Matterair pollutiondepressive symptomsepisodic memoryoldest-old

Identifiers

PMID33205418
PMCPMC8549784

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.