Evidence map›Paper›PMID 33205301›Full record

ArticleAmino acids2021

Monitoring peptide tyrosine nitration by spectroscopic methods.

Petr Niederhafner, Martin Šafařík, Jitka Neburková, Timothy A Keiderling, Petr Bouř, Jaroslav Šebestík

Abstract read
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In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Petr NiederhafnerInstitute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, 16610, Prague 6, Czech Republic.
Martin ŠafaříkInstitute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, 16610, Prague 6, Czech Republic.
Jitka NeburkováInstitute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, 16610, Prague 6, Czech Republic.
Timothy A KeiderlingDepartment of Chemistry, University of Illinois at Chicago, 845 W. Taylor St., Chicago, IL, 60607-7061, USA.
Petr BouřInstitute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, 16610, Prague 6, Czech Republic.ORCID http://orcid.org/0000-0001-8469-1686
Jaroslav ŠebestíkInstitute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, 16610, Prague 6, Czech Republic. sebestik@uochb.cas.cz.ORCID http://orcid.org/0000-0002-0614-2064
Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry · CZUniversity of Illinois Chicago · US

Funding

Grantová Agentura České Republiky 14-00431SGrantová Agentura České Republiky 17-00121SGrantová Agentura České Republiky 20-10144SMinisterstvo Školství, Mládeže a Tělovýchovy CZ.02.1.01/0.0/0.0/16_019/0000729
6 · The paper itself

Abstract

Oxidative stress can lead to various derivatives of the tyrosine residue in peptides and proteins. A typical product is 3-nitro-L-tyrosine residue (Nit), which can affect protein behavior during neurodegenerative processes, such as those associated with Alzheimer's and Parkinson's diseases. Surface enhanced Raman spectroscopy (SERS) is a technique with potential for detecting peptides and their metabolic products at very low concentrations. To explore the applicability to Nit, we use SERS to monitor tyrosine nitration in Met-Enkephalin, rev-Prion protein, and α-synuclein models. Useful nitration indicators were the intensity ratio of two tyrosine marker bands at 825 and 870 cm

Indexed as

Azo CompoundsCircular DichroismDensity Functional TheoryMolecular Dynamics SimulationPeptidesProtein Structure, SecondarySpectrum Analysis, RamanTyrosine3-nitrotyrosineazobenzeneAzo CompoundsPeptidesTyrosineDensity functional theory (DFT)Electronic circular dichroism (ECD)NitrationOxidative stressSurface-enhanced Raman spectroscopy (SERS)Vibrational circular dichroism (VCD)

Identifiers

PMID33205301
OpenAlexW3101744365

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.