ArticleJournal of molecular evolution2021
Richard Dickerson, Molecular Clocks, and Rates of Protein Evolution.
Article in Journal of molecular evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 citing papers in PubMed, 13 citations in OpenAlex.
- Evolution of the egg glue protein in great ape lice inferred from its sequence comparisons across five louse types.Scientific reports · 2025Article
- A unified analysis of evolutionary and population constraint in protein domains highlights structural features and pathogenic sites.Communications biology · 2024Article
- ProteinEvolverABC: coestimation of recombination and substitution rates in protein sequences by approximate Bayesian computation.Bioinformatics (Oxford, England) · 2021Article
- The Journal of Molecular Evolution Turns 50.Journal of molecular evolution · 2021Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Proteins approximately behave as molecular clocks, accumulating amino acid replacements at a more or less constant rate. Nonetheless, each protein displays a characteristic rate of evolution: whereas some proteins remain largely unaltered over large periods of time, others can rapidly accumulate amino acid replacements. An article by Richard Dickerson, published in the first issue of the Journal of Molecular Evolution (J Mol Evol 1:26-45, 1971), described the first analysis in which the rates of evolution of many proteins were compared, and the differences were interpreted in the light of their function. When comparing the sequences of fibrinopeptides, hemoglobin, and cytochrome c of different species, he observed a linear relationship between the number of amino acid replacements and divergence time. Remarkably, fibrinopeptides had evolved fast, cytochrome c had evolved slowly, and hemoglobin exhibited an intermediate rate of evolution. As the Journal of Molecular Evolution celebrates its 50th anniversary, I highlight this landmark article and reflect on its impact on the field of Molecular Evolution.
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