Evidence map›Paper›PMID 33205297›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

Early signs of metabolic syndrome in pediatric central nervous system tumor survivors after high-dose chemotherapy and autologous stem-cell transplantation and radiation.

Chantel Cacciotti, Muhammad Ali, Ute Bartels, Jonathan D Wasserman, Erilda Kapllani, Joerg Krueger, Eric Bouffet, Tal Schechter

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Chantel CacciottiDepartment of Pediatrics, McMaster Children's Hospital, Hamilton, ON, Canada. chantelcacciotti@gmail.com.ORCID 0000-0002-4968-8956
Muhammad AliDivision of Hematology-Oncology, Hospital for Sick Children, Toronto, ON, Canada.
Ute BartelsDivision of Hematology-Oncology, Hospital for Sick Children, Toronto, ON, Canada.
Jonathan D WassermanDivision of Endocrinology, Hospital for Sick Children, Toronto, ON, Canada.
Erilda KapllaniDivision of Hematology-Oncology, Hospital for Sick Children, Toronto, ON, Canada.
Joerg KruegerDivision of Hematology-Oncology, Hospital for Sick Children, Toronto, ON, Canada.
Eric BouffetDivision of Hematology-Oncology, Hospital for Sick Children, Toronto, ON, Canada.
Tal SchechterDivision of Hematology-Oncology, Hospital for Sick Children, Toronto, ON, Canada.
Hospital for Sick Children · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCancer survivors treated with stem-cell transplant (SCT) and radiation therapy are at a high risk for late effects including the metabolic syndrome. This study reviewed the prevalence of the metabolic syndrome in pediatric central nervous system (CNS) tumor survivors treated with autologous SCT and craniospinal radiation.

methodsA prospective, cross-sectional study in pediatric CNS tumor patients, who underwent a one-time evaluation at least 18 months post-autologous SCT for the presence of components of metabolic syndrome: obesity, hypertension, hyperlipidemia, and abnormal glucose levels.

resultsTwelve patients were evaluated, and two (16%) met full criteria for the metabolic syndrome. Seven patients (58%) had at least one component of metabolic syndrome: elevated glucose levels in 8% (1/12), obesity 17% (2/12), hypertriglyceridemia 17% (2/12), and reduced HDL cholesterol in 25% (3/12). None had hypertension. Nine patients (75%) demonstrated abnormal fasting lipid profiles with elevated total cholesterol levels, although only 25% (3/12) fulfilled criteria for a diagnosis of dyslipidemia.

conclusionPediatric CNS tumor survivors treated with autologous SCT and craniospinal radiation are at risk for early signs of metabolic syndrome, most commonly hyperlipidemia. Further studies evaluating the progression of these early signs to full criteria for the metabolic syndrome diagnosis are required.

Indexed as

Central Nervous System NeoplasmsHematopoietic Stem Cell TransplantationMetabolic SyndromeChildCross-Sectional StudiesHumansProspective StudiesRisk FactorsSurvivorsDyslipidemiaHypertensionObesityStem-cell transplantThe metabolic syndrome

Identifiers

PMID33205297
OpenAlexW3099735886

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.