Evidence map›Paper›PMID 33205281›Full record

Observational studyEuropean journal of clinical pharmacology2021

Potentially inappropriate medication in acute hospitalized elderly patients with polypharmacy: an observational study comparing PRISCUS, STOPP, and Beers criteria.

Lorena de Agustín Sierra, Jaime Rodríguez Salazar, Ana Belén Jiménez-Muñoz, María Jesús Molina Hernández, Paloma Bermejo Bescós, Irene Iglesias Peinado, Benito García Díaz

Erratum issuedAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of clinical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lorena de Agustín SierraServicio de Farmacia, Hospital Universitario Severo Ochoa, Avenida de Orellana, s/n., Leganés, Spain. lorena.deagustinsierra@gmail.com.ORCID https://orcid.org/0000-0003-0934-7599
Jaime Rodríguez SalazarServicio de Geriatría, Hospital Universitario Severo Ochoa, Avenida de Orellana, s/n, Leganés, Spain.
Ana Belén Jiménez-MuñozServicio de Medicina Preventiva, Hospital Universitario Severo Ochoa, Avenida de Orellana, s/n., Leganés, Spain.
María Jesús Molina HernándezServicio de Geriatría, Hospital Universitario Severo Ochoa, Avenida de Orellana, s/n, Leganés, Spain.
Paloma Bermejo BescósFacultad de Farmacia, Servicio de Farmacología y Farmacognosia, Spain, Universidad Complutense de Madrid, Avenida Plaza de Ramón y Cajal, s/n, 28040, Madrid, Spain.
Irene Iglesias PeinadoFacultad de Farmacia, Servicio de Farmacología y Farmacognosia, Spain, Universidad Complutense de Madrid, Avenida Plaza de Ramón y Cajal, s/n, 28040, Madrid, Spain.
Benito García DíazServicio de Farmacia, Hospital Universitario Severo Ochoa, Avenida de Orellana, s/n., Leganés, Spain.
Hospital Universitario Severo Ochoa · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the prevalence of potentially inappropriate medication (PIM) in the elderly according to the PRISCUS list, STOPP criteria, and Beers criteria. Secondary, to describe the differences using the three criteria focused on the inappropriate prescription of psychotropic drugs in the elderly.

methodsA retrospective study was performed at Severo Ochoa University Hospital. The study included 365 patients, aged 80 years and older, living in Madrid, Spain.

results93.42% of patients received at least one PIM during hospitalization. Using the PRISCUS list, this changed from 32.6 to 2.7% at discharge. Applying STOPP criteria lowered the percentage from 65.20 to 10.95%, and with Beers criteria from 80.27 to 10.13. Lower Barthel index at admission was associated with an increased relative risk for receiving at least one PIM (OR 1.79, 95% CI 1.15-2.80, p = 0.024) using PRISCUS list as a tool in conjunction with STOPP criteria (OR 1.44, 95% CI 0.89-2.33, p = 0.037). Polypharmacy at admission predicted the presence of PIMs with STOPP criteria (OR 1.74, 95% CI 1.07-2.84, p = 0.001). Regarding psychotropic medicines, 208 patients (56.98%) received at least one psychotropic medicine during hospitalization. A total of 26.30% of patients were treated with psychotropic medicines, detected by the PRISCUS list, and 53.97% and 29.85% with STOPP and Beers, respectively.

conclusionsExplicit criteria are a useful tool for identifying during hospitalization of the elderly patients. As indicated by the results, new research is needed to carry out an adaptation in our country that includes an evaluation of the strengths of the three tools to decrease PIMs and improve prescription in the elderly.

Indexed as

PolypharmacyAged, 80 and overFemaleHospitalizationHospitals, UniversityHumansInappropriate PrescribingMalePotentially Inappropriate Medication ListRetrospective StudiesSpainBeers criteriaElderlyPotentially inappropriate medicationPRISCUS listSTOPP/START

Identifiers

PMID33205281
OpenAlexW3098336952

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.