Evidence map›Paper›PMID 33205250›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2021

In vitro and in silico studies of 8(17),12E,14-labdatrien-18-oic acid in airways smooth muscle relaxation: new molecular insights about its mechanism of action.

Edilson B Alencar Filho, Luciano A A Ribeiro, Thiego G C Carvalho, Fabrício S Silva, Luiz Antonio M S Duarte-Filho, Euzébio G Barbosa, Pedro M N Menezes, Josean F Tavares, Marcelo S da Silva, Bagnólia A Silva

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Edilson B Alencar FilhoCollegiate of Pharmaceutical Sciences, Postgraduate Program in Biosciences (ex-Natural Resources of Semi-arid), Postgraduate Program in Health and Biological Sciences, Federal University of San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil. edilson.beserra@univasf.edu.br.ORCID 0000-0002-1000-0114
Luciano A A RibeiroCollegiate of Pharmaceutical Sciences, Postgraduate Program in Biosciences (ex-Natural Resources of Semi-arid), Federal University of San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil. luciano.ribeiro@univasf.edu.br.
Thiego G C CarvalhoCollegiate of Pharmaceutical Sciences, Postgraduate Program in Biosciences (ex-Natural Resources of Semi-arid), Postgraduate Program in Health and Biological Sciences, Federal University of San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil.
Fabrício S SilvaCollegiate of Pharmaceutical Sciences, Postgraduate Program in Biosciences (ex-Natural Resources of Semi-arid), Federal University of San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil.
Luiz Antonio M S Duarte-FilhoCollegiate of Pharmaceutical Sciences, Postgraduate Program in Biosciences (ex-Natural Resources of Semi-arid), Federal University of San Francisco Valley (UNIVASF), Petrolina, Pernambuco, Brazil.
Euzébio G BarbosaCollegiate of Pharmacy, Chemistry Laboratory, Lagoa Nova University Campus, Federal University of Rio Grande do Norte (UFRN), PO Box 1524, Natal, RN, CEP 59078-970, Brazil.
Pedro M N MenezesNortheast Biotechnology Network (RENORBIO), Federal Rural University of Pernambuco (UFRPE), Rua Dom R. Manuel de Medeiros, s / n, Dois Irmãos, Recife, PE, CEP 52171-900, Brazil.
Josean F TavaresPharmaceutical Technology Laboratory (LTF), Federal University of Paraíba (UFPB), Cidade Universitária, Castelo Branco, PO Box 5009, João Pessoa, PB, 58051-970, Brazil.
Marcelo S da SilvaPharmaceutical Technology Laboratory (LTF), Federal University of Paraíba (UFPB), Cidade Universitária, Castelo Branco, PO Box 5009, João Pessoa, PB, 58051-970, Brazil.
Bagnólia A SilvaPharmaceutical Technology Laboratory (LTF), Federal University of Paraíba (UFPB), Cidade Universitária, Castelo Branco, PO Box 5009, João Pessoa, PB, 58051-970, Brazil.
Universidade Federal do Vale do São Francisco · BRUniversidade Federal da Paraíba · BRUniversidade Federal do Rio Grande do Norte · BRUniversidade Federal Rural de Pernambuco · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the field of experimental pharmacology, researchers continuously investigate new relaxant agents of the airway smooth muscle cells (ASMCs), since the pathophysiology of respiratory illnesses, such as asthma, involves hyperresponsiveness and changes in ASMC homeostasis. In this scenario, labdane-type diterpenes, like forskolin (FSK), are a class of compounds known for their relaxing action on smooth muscle cells (SMCs), being this phenomenon related to the direct activation of AC-cAMP-PKA pathway. Considering the continuous effort of our group to study the mechanism of action and prospecting for compounds isolated from natural sources, in this paper, we presented how the diterpene 8(17),12E,14-labdatrien-18-oic acid (LBD) promotes relaxant effect on ASMC, performing in vitro experiments using isolated guinea pig trachea and in silico molecular docking/dynamics simulations. In vitro experiments showed that in the presence of aminophylline, FSK and LBD had their relaxant effect potentiated (EC

Indexed as

AminophyllineAnimalsBinding SitesColforsinComputer SimulationDiterpenesFemaleGuinea PigsMaleMolecular Docking SimulationMolecular Dynamics SimulationMuscle RelaxationMyocytes, Smooth MuscleTrachea8(17),12E,14-labdatrien-18-oic acidAminophyllineColforsinDiterpenesAdenylyl cyclase activatorLabdane-type diterpeneMolecular dynamics simulationsMolecular mechanism of actionMuscle relaxant effect

Identifiers

PMID33205250
OpenAlexW3099536662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.