ArticleBiology of reproduction2021
Negative impact of high doses of follicle-stimulating hormone during superovulation on the ovulatory follicle function in small ovarian reserve dairy heifers†.
Article in Biology of reproduction, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- A novel effect of sulforaphane on promoting mouse granulosa cells proliferation via the NRF2-TKT pathway.Journal of advanced research · 2025Article
- Development a Recombinant Protein (CrFSH) as a Reproductive Hormone for the Assisted Reproduction of Dairy Cows.Animals : an open access journal from MDPI · 2025Article
- A comparative study of intramuscular versus epidural administration of follicle-stimulating hormone for embryo production in Wagyu Cattle.Open veterinary journal · 2025Article
- Unraveling the Clinical FSH Conundrum: Insights From the Small Ovarian Reserve Heifer Model.Molecular reproduction and development · 2025Review
- Improving genetic gain in postpartum cows: a modified ovarian superstimulation protocol for ovum pick-up-in vitro embryo production during the voluntary waiting period.Journal of animal science · 2025Article
- Identification of candidate blood biomarkers through metabolomics analysis in bovine superovulation.Frontiers in veterinary science · 2025Article
- OptimizingAnimal reproduction · 2025Article
- Serum concentrations of anti-Müllerian hormone modulate ovarian response to different doses of follicle-stimulating hormone in Japanese Black donors.The Journal of reproduction and development · 2024Article
- Low ovarian responders produce more progesterone per follicle than normal and high responders.JBRA assisted reproduction · 2024Observational
- When Implementing the Presynch-11/Ovsynch Reproductive Management Program, the Fertility of Lactating Dairy Cows Improved When They Received Timed Artificial Insemination Compared with the Inclusion of Estrus Detection.Animals : an open access journal from MDPI · 2024Article
- A Dose-Response Study on Functional and Transcriptomic Effects of FSH on Ex Vivo Mouse Folliculogenesis.Endocrinology · 2024Article
- Nonlinear relationship between gonadotropin total dose applied and live birth rates in non-PCOS patients: a retrospective cohort study.Scientific reports · 2024Article
- Embryo production by Holstein heifers superovulated with a recombinant long-acting follicle-stimulating hormone analog.Journal of animal science · 2024Article
- Ovarian stimulation with excessive FSH doses causes cumulus cell and oocyte dysfunction in small ovarian reserve heifers.Molecular human reproduction · 2023Article
- Role of Date Palm Pollen on Heifer's Puberty and Maturity in Iraq.Archives of Razi Institute · 2023Article
- Follicular Hyperstimulation Dysgenesis: New Explanation for Adverse Effects of Excessive FSH in Ovarian Stimulation.Endocrinology · 2022Article
- Excessive follicle-stimulating hormone during ovarian stimulation of cattle may induce premature luteinization of most ovulatory-size follicles†.Biology of reproduction · 2022Article
- Limitations in use of ovarian reserve biomarkers to predict the superovulation response in small ovarian reserve heifers.Theriogenology · 2022Article
- High initial FSH dosage reduces the number of available cleavage-stage embryos in a GnRH-antagonist protocol: Real-world data of 8,772 IVF cycles from China.Frontiers in endocrinology · 2022Article
- FSH dose is negatively correlated with number of oocytes retrieved: analysis of a data set with ~650,000 ART cycles that previously identified an inverse relationship between FSH dose and live birth rate.Journal of assisted reproduction and genetics · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
When women with small ovarian reserves are subjected to assisted reproductive technologies, high doses of gonadotropins are linked to high oocyte and embryo wastage and low live birth rates. We hypothesized that excessive follicle-stimulating hormone (FSH) doses during superovulation are detrimental to ovulatory follicle function in individuals with a small ovarian reserve. To test this hypothesis, heifers with small ovarian reserves were injected twice daily for 4 days, beginning on Day 1 of the estrous cycle with 35, 70, 140, or 210 IU doses of Folltropin-V (FSH). Each heifer (n = 8) was superovulated using a Williams Latin Square Design. During each superovulation regimen, three prostaglandin F2α injections were given at 12-h interval, starting at the seventh FSH injection to regress the newly formed corpus luteum (CL). Human chorionic gonadotropin was injected 12 h after the last (8th) FSH injection to induce ovulation. Daily ultrasonography and blood sampling were used to determine the number and size of follicles and corpora lutea, uterine thickness, and circulating concentrations of estradiol, progesterone, and anti-Müllerian hormone (AMH). The highest doses of FSH did not increase AMH, progesterone, number of ovulatory-size follicles, uterine thickness, or number of CL. However, estradiol production and ovulation rate were lower for heifers given high FSH doses compared to lower doses, indicating detrimental effects on ovulatory follicle function.
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