Evidence map›Paper›PMID 33205074›Full record

ArticleCell reports. Medicine2020

A Small-Molecule Approach to Restore a Slow-Oxidative Phenotype and Defective CaMKIIβ Signaling in Limb Girdle Muscular Dystrophy.

Jian Liu, Jesus Campagna, Varghese John, Robert Damoiseaux, Ekaterina Mokhonova, Diana Becerra, Huan Meng, Elizabeth M McNally, April D Pyle, Irina Kramerova and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Current and Future Therapeutic Strategies for Limb Girdle Muscular Dystrophy Type R1: Clinical and Experimental Approaches.Pathophysiology : the official journal of the International Society for Pathophysiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jian LiuDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Jesus CampagnaDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Varghese JohnDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Robert DamoiseauxDepartment of Pharmacology, David Geffen School of Medicine and Molecular Screening Shared Resource, Crump Imaging Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Ekaterina MokhonovaDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Diana BecerraDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Huan MengDepartment of Medicine, David Geffen School of Medicine and California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Elizabeth M McNallyCenter for Genetic Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
April D PyleDepartment of Microbiology, Immunology and Medical Genetics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Irina KramerovaDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
Melissa J SpencerDepartment of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USCalifornia NanoSystems Institute · USNorthwestern University · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Training and education CoreU54AR052646 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI MCNALLY, ELIZABETH M, SWEENEY, H LEE · 2005 to 2020
$24.1M
Reprogramming and Directed Differentiation of Skeletal Muscle Cells from hPSCs.R01AR064327 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI April D Pyle · 2013 to 2026
$6.4M
UCLA Muscular Dystrophy Core CenterP30AR057230 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SPENCER, MELISSA JAN · 2009 to 2018
$6.2M
Mechanisms Underlying Limb Girdle Muscular Dystrophy2A Due to Calpain 3 MutationsR01AR048177 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SPENCER, MELISSA JAN · 2001 to 2016
$6.1M
Optimizing and validation of gene therapy vectors to treat limb girdle muscular dystophyR01NS117912 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHAMBERLAIN, JEFFREY S, SPENCER, MELISSA JAN · 2020 to 2024
$2.6M
NCATS NIH HHS UL1 TR001881NIAMS NIH HHS P30 AR057230NIAMS NIH HHS R01 AR048177NIAMS NIH HHS R01 AR064327NIAMS NIH HHS U54 AR052646NINDS NIH HHS R01 NS117912
6 · The paper itself

Abstract

Mutations in

Indexed as

AcyltransferasesAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2CalpainCardiac MyosinsCell LineCreatine Kinase, Mitochondrial FormFemaleGene Expression RegulationLipaseMaleMiceMice, Inbred C57BLMice, KnockoutMuscle ProteinsMuscle, SkeletalAcyltransferasesCalcium-Calmodulin-Dependent Protein Kinase Type 2CalpainCamk2b protein, mouseCapn3 protein, mouseCardiac MyosinsCkmt2 protein, mouseCreatine Kinase, Mitochondrial FormLipaseMuscle Proteinsmyosin light chain 2Myosin Light ChainsPNPLA2 protein, mouseProtein IsoformsPyrimidinesSmall Molecule Librariescalcium calmodulin kinasecalpaincalpainopathyCaMK signalingexercisefiber typehigh-throughput screenlimb girdle muscular dystrophymitochondriamuscle

Identifiers

PMID33205074
PMCPMC7659555
OpenAlexW3093487358

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.