Evidence map›Paper›PMID 33205072›Full record

ArticleCell reports. Medicine2020

Ureteral Stent Microbiota Is Associated with Patient Comorbidities but Not Antibiotic Exposure.

Kait F Al, John D Denstedt, Brendan A Daisley, Jennifer Bjazevic, Blayne K Welk, Stephen E Pautler, Gregory B Gloor, Gregor Reid, Hassan Razvi, Jeremy P Burton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kait F AlCentre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, ON, Canada.
John D DenstedtDivision of Urology, Department of Surgery, The University of Western Ontario, London, ON, Canada.
Brendan A DaisleyCentre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, ON, Canada.
Jennifer BjazevicDivision of Urology, Department of Surgery, The University of Western Ontario, London, ON, Canada.
Blayne K WelkDivision of Urology, Department of Surgery, The University of Western Ontario, London, ON, Canada.
Stephen E PautlerDivision of Urology, Department of Surgery, The University of Western Ontario, London, ON, Canada.
Gregory B GloorDepartment of Biochemistry, The University of Western Ontario, London, ON, Canada.
Gregor ReidCentre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, ON, Canada.
Hassan RazviDivision of Urology, Department of Surgery, The University of Western Ontario, London, ON, Canada.
Jeremy P BurtonCentre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, London, ON, Canada.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ureteral stents are commonly used to prevent urinary obstruction but can become colonized by bacteria and encrusted, leading to clinical complications. Despite recent discovery and characterization of the healthy urinary microbiota, stent-associated bacteria and their impact on encrustation are largely underexplored. We profile the microbiota of patients with typical short-term stents, as well as over 30 atypical cases (all with paired mid-stream urine) from 241 patients. Indwelling time, age, and various patient comorbidities correlate with alterations to the stent microbiota composition, whereas antibiotic exposure, urinary tract infection (UTI), and stent placement method do not. The stent microbiota most likely originates from adhesion of resident urinary microbes but subsequently diverges to a distinct, reproducible population, thereby negating the urine as a biomarker for stent encrustation or microbiota. Urological practice should reconsider standalone prophylactic antibiotics in favor of tailored therapies based on patient comorbidities in efforts to minimize bacterial burden, encrustation, and complications of ureteral stents.

Indexed as

AdultAnti-Bacterial AgentsCanadaComorbidityDevice RemovalFemaleHumansMaleMicrobiotaMiddle AgedStentsUreterAnti-Bacterial Agentsantibioticsendourologymedical microbiologymicrobiotaureteral stentsurology

Identifiers

PMID33205072
PMCPMC7659606
OpenAlexW3088054556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.