Evidence map›Paper›PMID 33205069›Full record

ArticleCell reports. Medicine2020

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk.

Mark R Davies, Michael Martinec, Robert Walls, Roman Schwarz, Gary R Mirams, Ken Wang, Guido Steiner, Andy Surinach, Carlos Flores, Thierry Lavé and 2 more

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mark R DaviesQT-Informatics Ltd., Macclesfield, UK.
Michael MartinecPHC Data Science, Personalized Healthcare, Product Development, F. Hoffmann-La Roche AG, Basel, Switzerland.
Robert WallsPHC Data Science, Personalized Healthcare, Product Development, F. Hoffmann-La Roche AG, Basel, Switzerland.
Roman SchwarzSafety Analytics and Reporting, Drug Safety, Pharmaceutical Development, F. Hoffmann-La Roche AG, Basel, Switzerland.
Gary R MiramsCentre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
Ken WangRoche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.
Guido SteinerRoche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.
Andy SurinachGenesis Research, Hoboken, NJ, USA.
Carlos FloresGenesis Research, Hoboken, NJ, USA.
Thierry LavéRoche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.
Thomas SingerRoche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.
Liudmila PolonchukRoche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.

Funding

Wellcome Trust 212203/Z/18/Z
6 · The paper itself

Abstract

There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of high-throughput

Indexed as

AdultAdverse Drug Reaction Reporting SystemsAlgorithmsAnimalsArrhythmias, CardiacCell LineCHO CellsComputer SimulationCricetulusDatabases, FactualData CollectionFemaleHumansMalePharmaceutical PreparationsRisk AssessmentPharmaceutical Preparationsarrhythmiacardiac safetydrug developmentin silico modelsreal world data

Identifiers

PMID33205069
PMCPMC7659582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.