Evidence map›Paper›PMID 33205068›Full record

ArticleCell reports. Medicine2020

Malignant Transformation Involving

Patricia A Olofsen, Szabolcs Fatrai, Paulina M H van Strien, Julia C Obenauer, Hans W J de Looper, Remco M Hoogenboezem, Claudia A J Erpelinck-Verschueren, Michael P W M Vermeulen, Onno Roovers, Torsten Haferlach and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports. Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  8. The role of GATA2 in adult hematopoiesis and cell fate determination.Frontiers in cell and developmental biology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Patricia A OlofsenDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Szabolcs FatraiDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Paulina M H van StrienDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Julia C ObenauerDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Hans W J de LooperDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Remco M HoogenboezemDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Claudia A J Erpelinck-VerschuerenDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Michael P W M VermeulenDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Onno RooversDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Torsten HaferlachMunich Leukemia Laboratory (MLL), Munich 81377, Germany.
Joop H JansenDepartment of Laboratory Medicine, Radboud University Medical Center, Nijmegen 6525 GA, the Netherlands.
Mehrnaz GhazviniDepartment of Developmental Biology, iPS Core Facility, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Eric M J BindelsDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Rebekka K SchneiderDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Emma M de PaterDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Ivo P TouwDepartment of Hematology, Erasmus University Medical Center, Rotterdam 3015 CN, the Netherlands.
Erasmus MC · NLMunich Leukemia Laboratory (Germany) · DERadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe congenital neutropenia (SCN) patients treated with CSF3/G-CSF to alleviate neutropenia frequently develop acute myeloid leukemia (AML). A common pattern of leukemic transformation involves the appearance of hematopoietic clones with CSF3 receptor (

Indexed as

AnimalsCell LineCell Line, TumorCell Transformation, NeoplasticCongenital Bone Marrow Failure SyndromesCore Binding Factor Alpha 2 SubunitDNA-Binding ProteinsHEK293 CellsHumansInflammationK562 CellsLeukemia, Myeloid, AcuteMiceMutationNeutropeniaSignal TransductionCore Binding Factor Alpha 2 SubunitCXXC4 protein, humanDNA-Binding ProteinsTranscription FactorsAMLCSF3RCXXC4growth factor therapyleukemia predispositionpro-inflammatory signalingRUNX1severe congenital neutropeniaTET2

Identifiers

PMID33205068
PMCPMC7659587
OpenAlexW3081057257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.