Evidence map›Paper›PMID 33205038›Full record

ArticleJournal of translational autoimmunity2020

Serological comparison of systemic lupus erythematosus with neuropsychiatric lupus using synthetic nucleic acid antigens.

Sangita Khatri, Nikos Psaraftis, Alessia Funaro, Yoshiyuki Arinuma, Yuichiro Fujieda, Simone Mader, Christian Damsgaard Jørgensen, Kira Astakhova

Open access · goldAbstract read
In one paragraph

Article in Journal of translational autoimmunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Sangita KhatriDepartment of Chemistry, Technical University of Denmark, 207 Kemitorvet, 2800, Kgs. Lyngby, Denmark.
Nikos PsaraftisDepartment of Chemistry, Technical University of Denmark, 207 Kemitorvet, 2800, Kgs. Lyngby, Denmark.
Alessia FunaroDepartment of Chemistry, Technical University of Denmark, 207 Kemitorvet, 2800, Kgs. Lyngby, Denmark.
Yoshiyuki ArinumaDepartment of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, 1-15-1, Minamiku, Kitasato, Sagamihara, Kanagawa, 252-0374, Japan.
Yuichiro FujiedaDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
Simone MaderInstitute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians University Munich, Martinsried, Germany.
Christian Damsgaard JørgensenDepartment of Mathematics and Computer Science, University of Southern Denmark, 5230, Odense M, Denmark.
Kira AstakhovaDepartment of Chemistry, Technical University of Denmark, 207 Kemitorvet, 2800, Kgs. Lyngby, Denmark.
Technical University of Denmark · DKHokkaido University · JPKitasato University · JPLudwig-Maximilians-Universität München · DEUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropsychiatric systemic lupus erythematosus is an autoimmune disorder characterized by an irregular exchange between the central nervous system and the immune system, leading to the outbreak of neurological conditions with possible disabling effects. Although neuropsychiatric systemic lupus erythematosus is the most common expression of lupus condition, it is still poorly understood. In this study, we focus on the development of an advantageous method based on the application of synthetic nucleic acids and protein-based antigen arrays in order to characterize autoreactive antibodies in neuropsychiatric systemic lupus erythematosus. We confirmed the benefits of using synthetic oligonucleotides such as assay reproducibility, elevated affinity and specificity to autoreactive antibodies. We also demonstrated presence of autoantibodies towards three particular synthetic double stranded antigens and verify similarity of antinuclear antibody patterns in ordinary lupus and neuropsychiatric systemic lupus erythematosus.

Indexed as

Autoreactive antibodiesEnzyme-Linked Immunosorbent assayNeuropsychiatric systemic lupus erythematosusOligonucleotidesSynthetic Antigens

Identifiers

PMID33205038
PMCPMC7652778
OpenAlexW3094954774

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.