Evidence map›Paper›PMID 33204698›Full record

ArticleBioMed research international2020

Characterization of Oral Microbiome and Exploration of Potential Biomarkers in Patients with Pancreatic Cancer.

Haiyang Sun, Xia Zhao, Yanxia Zhou, Jun Wang, Rui Ma, Xi Ren, Huaizhi Wang, Lingyun Zou

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  8. Saliva assay: a call for methodological standardization.Journal of periodontal & implant science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Haiyang SunShenzhen Baoan Women's and Children's Hospital, Jinan University, 518102 Shenzhen, China.
Xia ZhaoBioinformatics Center, Department of Microbiology, Army Medical University, 400038 Chongqing, China.
Yanxia ZhouShenzhen Baoan Women's and Children's Hospital, Jinan University, 518102 Shenzhen, China.
Jun WangShenzhen Baoan Women's and Children's Hospital, Jinan University, 518102 Shenzhen, China.
Rui MaShenzhen Baoan Women's and Children's Hospital, Jinan University, 518102 Shenzhen, China.
Xi RenShenzhen Baoan Women's and Children's Hospital, Jinan University, 518102 Shenzhen, China.
Huaizhi WangInstitute of Hepatopancreatobiliary Surgery, Chongqing General Hospital, University of Chinese Academy of Sciences, China.ORCID https://orcid.org/0000-0002-5421-5176
Lingyun ZouShenzhen Baoan Women's and Children's Hospital, Jinan University, 518102 Shenzhen, China.ORCID https://orcid.org/0000-0002-1109-5709
Jinan University · CNArmy Medical University · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer (PC) is highly malignant and lacks an effective therapeutic schedule, hence that early diagnosis is of great importance to achieve a good prognosis. Oral bacteria have been proved to be associated with pancreatic cancer, but the specific mechanism has not been comprehensively illustrated. In our study, thirty-seven saliva samples in total were collected with ten from PC patients, seventeen from benign pancreatic disease (BPD) patients, and ten from healthy controls (HC). The oral bacterial community of HC, PC, and BPD groups was profiled by 16S rDNA high-throughput sequencing and bioinformatic methods. As shown by Simpson, Inverse Simpson, Shannon and Heip, oral microbiome diversity of HC, BPD and PC groups is in increasing order with the BPD and PC groups significantly higher than the HC group. Principal coordinate analysis (PCoA) suggested that grouping by PC, BPD and HC was statistically significant. The linear discriminant analysis effect size (LEfSe) identified high concentrations of

Indexed as

Biomarkers, TumorCase-Control StudiesFemaleFusobacteriumHumansMaleMicrobiotaMouth MucosaNeisseria mucosaPancreatic DiseasesPancreatic NeoplasmsSalivaBiomarkers, Tumor

Identifiers

PMID33204698
PMCPMC7652608
OpenAlexW3097827147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.