Evidence map›Paper›PMID 33204638›Full record

ArticleMolecular genetics and metabolism reports2020

Arginine kinetics are altered in a pilot sample of adolescents and young adults with Barth syndrome.

W Todd Cade, Kathryn L Bohnert, Adam J Bittel, Shaji J Chacko, Bruce W Patterson, Christina A Pacak, Barry J Byrne, Hilary J Vernon, Dominic N Reeds

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. A Barth Syndrome Patient-DerivedInternational journal of molecular sciences · 2024
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

W Todd CadeProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, United States.
Kathryn L BohnertProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, United States.
Adam J BittelProgram in Physical Therapy, Washington University School of Medicine, St. Louis, MO, United States.
Shaji J ChackoDepartment of Pediatrics, Children's Nutrition Research Center, U.S. Department of Agriculture/Agricultural Research Service, Baylor College of Medicine, Houston, TX, United States.
Bruce W PattersonDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Christina A PacakDepartment of Pediatrics, University of Florida School of Medicine, Gainesville, FL, United States.
Barry J ByrneDepartment of Pediatrics, University of Florida School of Medicine, Gainesville, FL, United States.
Hilary J VernonDepartment of Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Dominic N ReedsDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Washington University in St. Louis · USUniversity of Florida · USAgricultural Research Service · USJohns Hopkins Medicine · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
Mechanisms and Treatment of Cardiac and Skeletal Muscular Dysfunction in Barth SyndromeR01HL136759 · NHLBI · UNIVERSITY OF MINNESOTA · PI PACAK, CHRISTINA A. · 2018 to 2022
$2.2M
NCATS NIH HHS UL1 TR002345NHLBI NIH HHS R01 HL136759NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

Barth syndrome (BTHS) is a rare, X-linked cardiomyopathy that is characterized by abnormalities in glucose and lipid metabolism, with less known regarding amino acid metabolism. This pilot study characterized whole-body arginine kinetics and found lower arginine rate of appearance into plasma (0.69 ± 0.09 vs. 0.88 ± 0.06 μmol/kgFFM/min,

Indexed as

Amino acidBarth syndromeMetabolismMitochondria

Identifiers

PMID33204638
PMCPMC7649643
OpenAlexW3094943796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.