Evidence map›Paper›PMID 33204569›Full record

ArticleCase reports in urology2020

Pathologic Complete Response to Neoadjuvant Nivolumab/Ipilimumab in a Patient with Metastatic Renal Cell Carcinoma.

Taylor C Peak, Elena M Fenu, Michael B Rothberg, Christopher Y Thomas, Ronald L Davis, Edward A Levine

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Taylor C PeakDepartment of Urology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.ORCID https://orcid.org/0000-0003-4541-1105
Elena M FenuDepartment of Pathology, Wake Forest Baptist Medical Center, Winston-Salem NC, USA.ORCID https://orcid.org/0000-0001-9523-9222
Michael B RothbergDepartment of Urology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.ORCID https://orcid.org/0000-0003-2062-6329
Christopher Y ThomasDepartment of Medical Oncology and Hematology, Wake Forest Baptist Medical Center, Winston-Salem NC, USA.ORCID https://orcid.org/0000-0001-9204-741X
Ronald L DavisDepartment of Urology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.ORCID https://orcid.org/0000-0003-3235-0032
Edward A LevineSurgical Oncology Service, Department of General Surgery, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.ORCID https://orcid.org/0000-0002-7683-9502
Atrium Health Wake Forest Baptist · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nivolumab plus ipilimumab represents an effective combination of checkpoint inhibitors that can lead to a durable response with minimal toxicity in patients with metastatic renal cell carcinoma (mRCC). We present a case of a pathologic complete response to neoadjuvant nivolumab plus ipilimumab in a patient with a 13.9 cm left renal mass and significant retroperitoneal and iliac lymphadenopathy, classified as intermediate-risk mRCC. We discuss and review the literature on complete responses after systemic therapy and the ability to predict who has undergone a complete response in the face of residual radiographic evidence of disease.

Identifiers

PMID33204569
PMCPMC7652618
OpenAlexW3094927297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.