ReviewEFORT open reviews2020
Frontiers in non-union research.
Review in EFORT open reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Identification of biomechanical alterations associated with nonunion after tibial shaft fractures using musculoskeletal simulation based on motion capture and instrumented insole data.Archives of orthopaedic and trauma surgery · 2026Article
- Salvage of Complex Bimalleolar Ankle Fracture Non-union after Failed Tibiotalocalcaneal and Charnley Arthrodesis using Fibular Strut Grafting and Ilizarov Fixation: A Case Report.Journal of orthopaedic case reports · 2026Article
- Long-term radiological and clinical outcomes after surgical treatment of non-union: a ten-year follow-up study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Article
- Article
- Treatment of Diaphyseal Tibial Non-unions After Open Fracture: A Retrospective Observational Study on Characteristics and Outcomes.Indian journal of orthopaedics · 2024Article
- Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?Bioengineering (Basel, Switzerland) · 2024Article
- Management of non-unions of the malleolar fractures- Current Evidence.Journal of clinical orthopaedics and trauma · 2024Article
- Gait Analysis to Monitor Fracture Healing of the Lower Leg.Bioengineering (Basel, Switzerland) · 2023Review
- Article
- Human Non-Hypertrophic Nonunion Tissue Contains Osteoblast Lineage Cells and E-BMP-2 Activates Osteogenic and Chondrogenic Differentiation.Current issues in molecular biology · 2022Article
- Adipose-derived mesenchymal stem cells combined with platinum nanoparticles accelerate fracture healing in a rat tibial fracture model.Annals of translational medicine · 2022Article
- Bone Healing Materials in the Treatment of Recalcitrant Nonunions and Bone Defects.International journal of molecular sciences · 2022Review
- Cross-sectional Vascularization Pattern of the Adipofascial Anterolateral Thigh Flap for Application in Tissue-engineered Bone Grafts.Plastic and reconstructive surgery. Global open · 2022Article
- Bone morphogenetic protein 2-induced cellular chemotaxis drives tissue patterning during critical-sized bone defect healing: an in silico study.Biomechanics and modeling in mechanobiology · 2021Article
- The Association Between Diagnosed Cannabis Use Disorder and Post-Operative Outcomes in Lower Extremity Trauma Patients: A Retrospective Database Review.Journal of orthopaedic experience & innovationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multifactorial aetiology defines non-unions, with a biological and a mechanical distortion of the timeline of bone healing.Research on new advances to increase osteogenesis and promote non-union healing is strongly directed towards new forms of cell products.Basic science and research on non-union treatments is needed to compile preclinical data on new treatments.Bone marrow concentration and expanded mesenchymal stromal cells still require extensive clinical research to confirm efficacy in non-union treatment.Solid preclinical studies, precise cell product definition and preparation, and appropriate ethical and regulatory approvals are needed to assess new advanced therapy medicinal products. Cite this article:
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.