Evidence map›Paper›PMID 33204460›Full record

ArticleRoyal Society open science2020

An integrative machine learning approach to discovering multi-level molecular mechanisms of obesity using data from monozygotic twin pairs.

Milla Kibble, Suleiman A Khan, Muhammad Ammad-Ud-Din, Sailalitha Bollepalli, Teemu Palviainen, Jaakko Kaprio, Kirsi H Pietiläinen, Miina Ollikainen

Abstract read
In one paragraph

Article in Royal Society open science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. A Systematic Review on Applications of Artificial Intelligence for Obesity Prevention.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Milla KibbleInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1130-4010
Suleiman A KhanInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0823-4042
Muhammad Ammad-Ud-DinInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Sailalitha BollepalliInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-8773-7149
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-7847-8384
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455
Kirsi H PietiläinenObesity Research Unit, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.ORCID 0000-0002-8522-1288
Miina OllikainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0003-3661-7400

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We combined clinical, cytokine, genomic, methylation and dietary data from 43 young adult monozygotic twin pairs (aged 22-36 years, 53% female), where 25 of the twin pairs were substantially weight discordant (delta body mass index > 3 kg m

Indexed as

big datamachine learningmonozygotic twinsobesity

Identifiers

PMID33204460
PMCPMC7657920

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.