Evidence map›Paper›PMID 33204402›Full record

ArticleOxidative medicine and cellular longevity2020

Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NF

Xiaoqin Ding, Tunyu Jian, Jiawei Li, Han Lv, Bei Tong, Jing Li, Xiuhua Meng, Bingru Ren, Jian Chen

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 99 citations in OpenAlex.

  1. Chicoric acid enhanced brain cholesterol efflux and reduced Aβ pathology via LXR-ABCA1 signaling in Alzheimer's models.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Animals : an open access journal from MDPI · 2026
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  6. Article
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  9. Review
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  11. Metabolic stress and age drive inflammation and cognitive decline in mice and humans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  12. Quercetin attenuates the symptoms of osteoarthritisMolecular medicine reports · 2025
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Water Extract ofInternational journal of molecular sciences · 2024
    Article
  20. Protective Potential ofInternational journal of molecular sciences · 2024
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaoqin DingInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.ORCID https://orcid.org/0000-0002-9365-6396
Tunyu JianInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.ORCID https://orcid.org/0000-0002-9814-500X
Jiawei LiInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.ORCID https://orcid.org/0000-0002-6253-1582
Han LvInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.ORCID https://orcid.org/0000-0003-4452-4351
Bei TongInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.ORCID https://orcid.org/0000-0002-6863-6019
Jing LiDepartment of Food Science and Technology, College of Light Industry and Food Engineering, Nanjing Forestry University, Nanjing 210037, China.ORCID https://orcid.org/0000-0002-2169-1512
Xiuhua MengInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.ORCID https://orcid.org/0000-0002-2249-3649
Bingru RenInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.ORCID https://orcid.org/0000-0003-1398-4953
Jian ChenInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.ORCID https://orcid.org/0000-0003-0686-833X
Chinese Academy of Sciences · CNNanjing Forestry University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examines the effects of chicoric acid (CA) on nonalcoholic fatty liver disease (NAFLD) in high-fat-diet- (HFD-) fed C57BL/6 mice. CA treatment decreased body weight and white adipose weight, mitigated hyperglycemia and dyslipidemia, and reduced hepatic steatosis in HFD-fed mice. Moreover, CA treatment reversed HFD-induced oxidative stress and inflammation both systemically and locally in the liver, evidenced by the decreased serum malondialdehyde (MDA) abundance, increased serum superoxide dismutase (SOD) activity, lowered

Indexed as

AMP-Activated Protein KinasesAnimalsCaffeic AcidsDiet, High-FatGastrointestinal MicrobiomeHep G2 CellsHIV Integrase InhibitorsHumansLipid MetabolismMaleMiceMice, Inbred C57BLNF-E2-Related Factor 2NF-kappa BNon-alcoholic Fatty Liver DiseaseOxidative StressAMP-Activated Protein KinasesCaffeic Acidschicoric acidHIV Integrase InhibitorsNF-E2-Related Factor 2NF-kappa BSuccinates

Identifiers

PMID33204402
PMCPMC7657699
OpenAlexW3096840257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.