ReviewThe World Allergy Organization journal2020
A systematic review and meta-analysis of risk factors associated with atopic dermatitis in Asia.
Review in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Prevalence of eczema between cesarean-born and vaginal-born infants within 1 year of age: a systematic review and meta-analysis.European journal of pediatrics · 2022Pooled it
- Irritable Bowel Syndrome and Allergic Diseases: A Nationwide Study of 1.5 Million Adolescents.Digestive diseases and sciences · 2026Article
- Targeting Pollutants in the Treatment and Prevention of Atopic Dermatitis.Immunology and allergy clinics of North America · 2025Review
- The clinical, mechanistic, and social impacts of air pollution on atopic dermatitis.The Journal of allergy and clinical immunology · 2024Review
- Association between exposure to ambient air pollution, meteorological factors and atopic dermatitis consultations in Singapore-a stratified nationwide time-series analysis.Scientific reports · 2024Article
- In Vitro Anti-Inflammatory and Skin Protective Effects ofJournal of microbiology and biotechnology · 2024Article
- The burden of dermatitis from 1990-2019 in the Middle East and North Africa region.BMC public health · 2024Article
- Intermittent or Sequential Topical Tacrolimus in Atopic Dermatitis: Systematic Review and Meta-Analysis.Cureus · 2023Review
- Dietary Protein Intake and Associated Risks for Atopic Dermatitis, Intrinsic Eczema, and Allergic Sensitization among Young Chinese Adults in Singapore/Malaysia: Key Findings from a Cross-sectional Study.JID innovations : skin science from molecules to population health · 2023Article
- Pimecrolimus for the Treatment of Atopic Dermatitis in Infants: An Asian Perspective.Dermatology and therapy · 2023Review
- Health Behavior and Social-Emotional Health Status of School-Aged Children According to their Experience with Atopic Dermatitis Diagnosis: Based on the 12th (2019) Panel Study on Korean Children.Children (Basel, Switzerland) · 2023Article
- An update on the prevalence, chronicity, and severity of atopic dermatitis and the associated epidemiological risk factors in the Singapore/Malaysia Chinese young adult population: A detailed description of the Singapore/Malaysia Cross-Sectional Genetics Epidemiology Study (SMCGES) cohort.The World Allergy Organization journal · 2022Article
- No Association Between First Exposure to General Anaesthesia and Atopic Dermatitis in the Paediatric Population.Acta dermato-venereologica · 2022Article
- Prenatal and perinatal risk factors of food allergy in Taiwanese young children.The World Allergy Organization journal · 2022Article
- National Saudi Consensus Statement on the Management of Atopic Dermatitis (2021).Dermatology and therapy · 2022Review
- Obesity is a risk factor for decrease in lung function after COVID-19 infection in children with asthma.Pediatric pulmonology · 2022Article
- AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis.Antioxidants (Basel, Switzerland) · 2022Review
- Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children.Frontiers in pediatrics · 2022Article
- Phenotypes of atopic dermatitis up to 36 months of age by latent class analysis and associated factors in Japan.Asia Pacific allergy · 2022Article
- The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtopic dermatitis (AD) is a chronic, inflammatory skin disorder characterised by intense itch and eczematous lesions. Rising prevalence of AD has been observed worldwide including in Asia. Understanding the risk factors associated with AD may explain its pathogenicity and identify new preventive strategies and treatments. However, AD-associated risk factors and comorbidities specific to Asia have not been systematically reviewed.
methodsWe performed a systematic review in accordance with the Preferred Reporting Item for Systematic Review and Meta-Analyses (PRISMA) guidelines and summarised epidemiological studies investigating personal, family, and environmental factors and comorbidities associated with AD in Asia. Significant factors were assessed if they can be altered through lifestyle practices and further classified into non-modifiable and modifiable factors. Meta-analysis using the random-effect model was also conducted to provide an overall estimate for several significant factors.
resultsWe identified a total of 162 epidemiological studies conducted in Asia. Among non-modifiable factors, a family history of atopic diseases was the most reported, suggesting the involvement of genetics in AD pathogenesis. Among modifiable factors, the results of meta-analyses revealed maternal smoking as the strongest risk factor with a pooled odds ratio (OR) of 2.95 (95% CI, 2.43-3.60), followed by active smoking (pooled OR, 1.91, 95% CI, 1.41-2.59).
conclusionWhile a family history may aid clinicians in identifying high-risk individuals, literature has long suggested the importance of gene-environment interaction. This review identified several modifiable factors including medical treatments, indoor and outdoor environmental exposure, and personal and family lifestyle specific to Asia. Based on the meta-analyses performed, prevention strategies against AD may start from changing personal and family lifestyle choices, especially smoking habits.
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