Evidence map›Paper›PMID 33204369›Full record

ReviewThe EPMA journal2020

Infections of the lung: a predictive, preventive and personalized perspective through the lens of evolution, the emergence of SARS-CoV-2 and its pathogenesis.

Pankaj Ahluwalia, Meenakshi Ahluwalia, Kumar Vaibhav, Ashis Mondal, Nikhil Sahajpal, Shaheen Islam, Sadanand Fulzele, Vamsi Kota, Krishnan Dhandapani, Babak Baban and 2 more

Open access · bronzeAbstract readReview
In one paragraph

Review in The EPMA journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Pankaj AhluwaliaDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA USA.
Meenakshi AhluwaliaDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA USA.
Kumar VaibhavDepartment of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA USA.
Ashis MondalDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA USA.
Nikhil SahajpalDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA USA.
Shaheen IslamDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA USA.
Sadanand FulzeleDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA USA.
Vamsi KotaDepartment of Medicine, Medical College of Georgia, Augusta University, Augusta, GA USA.
Krishnan DhandapaniDepartment of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA USA.
Babak BabanDepartment of Oral Biology, Medical College of Georgia, Augusta University, Augusta, GA USA.
Amyn M RojianiDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA USA.
Ravindra KolheDepartment of Pathology, Medical College of Georgia, Augusta University, Augusta, GA USA.ORCID 0000-0002-8283-2403
Augusta University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The long evolutionary battle between humans and pathogens has played an important role in shaping the current network of host-pathogen interactions. Each organ brings new challenges from the perspective of a pathogen to establish a suitable niche for survival while subverting the protective mechanisms of the host. Lungs, the organ for oxygen exchange, have been an easy target for pathogens due to its accessibility. The organ has evolved diverse capabilities to provide the flexibility required for an organism's health and at the same time maintain protective functionality to prevent and resolve assault by pathogens. The pathogenic invasions are strongly challenged by healthy lung architecture which includes the presence and activity of the epithelium, mucous, antimicrobial proteins, surfactants, and immune cells. Competitively, the pathogens in the form of viruses, bacteria, and fungi have evolved an arsenal of strategies that can over-ride the host's protective mechanisms. While bacteria such as

Indexed as

ComorbiditiesCOVID-19Disease managementFuture healthcareHealth policyHost-pathogen interactionImmunityIndividualized patient profileInflammationLungsMicrobiologyM. tuberculosisMulti-professional expertisePatient stratificationPhenotypingPolicy makersPredictive preventive personalized medicine (PPPM)SARS-CoV-2Therapeutic strategiesVirology

Identifiers

PMID33204369
PMCPMC7661834
OpenAlexW3098687778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.