Evidence map›Paper›PMID 33204323›Full record

ArticleTheranostics2020

Discovery and validation of miR-452 as an effective biomarker for acute kidney injury in sepsis.

Zhiwen Liu, Danyi Yang, Jingli Gao, Xiaohong Xiang, Xiaoru Hu, Siyao Li, Wenwen Wu, Juan Cai, Chengyuan Tang, Dongshan Zhang and 1 more

Open access · goldAbstract readValidation Study
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 2 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. SUMOylation protects against sepsis-associated acute kidney injury by stabilizing IκBα.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. 2D TiMikrochimica acta · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Biological attributes of zinc-dependent endopeptidases in endothelial dysfunction associated with sepsis: a narrative review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  17. Review
  18. Article
  19. Review
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Zhiwen LiuDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Danyi YangDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Jingli GaoDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Xiaohong XiangDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Xiaoru HuDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Siyao LiDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Wenwen WuDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Juan CaiDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Chengyuan TangDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Dongshan ZhangDepartment of Emergency Medicine, The Second Xiangya Hospital at Central South University, Changsha, Hunan, China.
Zheng DongDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification.
Second Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Early DiagnosisAcute Kidney InjuryAnimalsBiomarkersCase-Control StudiesCell LineDisease Models, AnimalFemaleHealthy VolunteersHumansInsulin-Like Growth Factor Binding ProteinsKidneyLipopolysaccharidesMaleMiceMicroRNAsBiomarkersinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsLipopolysaccharidesMicroRNAsMIRN452 microRNA, humanMIRN452 microRNA, mouseTIMP2 protein, humanTissue Inhibitor of Metalloproteinase-2acute kidney injurybiomarkermicroRNANF-κBsepsis

Identifiers

PMID33204323
PMCPMC7667674
OpenAlexW3094930179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.