Evidence map›Paper›PMID 33204291›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2020

Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19.

Wenhao Niu, Feng Wu, Haiming Cui, Wenyue Cao, YuChieh Chao, Zonggui Wu, Min Fan, Chun Liang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. The Role of Ursodeoxycholic Acid Administration During the COVID-19 Pandemic: A Questionnaire Survey.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Review
  11. Review on the Diverse Biological Effects of Glabridin.Drug design, development and therapy · 2023
    Review
  12. Article
  13. Review
  14. Article
  15. miRNAs: The Key Regulator of COVID-19 Disease.International journal of cell biology · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wenhao NiuDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200001, China.
Feng WuDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200080, China.
Haiming CuiDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200080, China.
Wenyue CaoDepartment of Ultrasound, Shanghai Chest Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China.
YuChieh ChaoDepartment of Anesthesiology, Shanghai Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200120, China.
Zonggui WuDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200080, China.
Min FanDepartment of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai 200080, China.
Chun LiangDepartment of Cardiology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200001, China.ORCID https://orcid.org/0000-0002-4042-206X
Shanghai University of Traditional Chinese Medicine · CNSecond Military Medical University · CNRenji Hospital · CNShanghai Chest Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

"Three formulas and three medicines," which include Jinhua Qinggan granule, Lianhua Qingwen capsule/granule, Xuebijing injection, Qingfei Paidu decoction, HuaShiBaiDu formula, and XuanFeiBaiDu granule, have been proven to be effective in curbing coronavirus disease 2019 (COVID-19), according to the State Administration of Traditional Chinese Medicine. The aims of this study were to identify the active components of "Three formulas and three medicines" that can be used to treat COVID-19, determine their mechanism of action via angiotensin-converting enzyme 2 (ACE2) by integrating network pharmacological approaches, and confirm the most effective components for COVID-19 treatment or prevention. We investigated all the compounds present in the aforementioned herbal ingredients. Compounds that could downregulate the transcription factors (TFs) of ACE2 and upregulate miRNAs of ACE2 were screened via a network pharmacology approach. Hepatocyte nuclear factor 4 alpha (HNF4A), peroxisome proliferator-activated receptor gamma (PPARG), hsa-miR-2113, and hsa-miR-421 were found to regulate ACE2. Several compounds, such as quercetin, decreased ACE2 expression by regulating the aforementioned TFs or miRNAs. After comparison with the compounds present in

Identifiers

PMID33204291
PMCPMC7661114
OpenAlexW3094741478

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.