Evidence map›Paper›PMID 33204265›Full record

ReviewJournal of oncology2020

Cervical Cancer Screening Guidelines in the Postvaccination Era: Review of the Literature.

Carlo A Liverani, Jacopo Di Giuseppe, Luca Giannella, Giovanni Delli Carpini, Andrea Ciavattini

Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Journal of oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05267834 (In Situ/Microinvasive Adenocarcinoma of the Uterine Cervix and HPV-type Impact), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05267834 completednot on this mapstarted 2022, after this paper: background citation

In Situ/Microinvasive Adenocarcinoma of the Uterine Cervix and HPV-type Impact: Pathologic Features, Treatment Options, and Follow-up Outcomes - Cervical Adenocarcinoma Study Group (CAS-Group).

TypeobservationalSponsorUniversità Politecnica delle MarcheRan2022 to 2023Enrolled148ConditionsAdenocarcinoma of the Uterine CervixArmsConization and/or Hysterectomy
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Carlo A LiveraniDepartment of Gynecology, Humanitas San Pio X, Milano 20159, Italy.ORCID https://orcid.org/0000-0003-2796-1824
Jacopo Di GiuseppeWoman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona 60100, Italy.ORCID https://orcid.org/0000-0002-6162-6299
Luca GiannellaWoman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona 60100, Italy.ORCID https://orcid.org/0000-0002-6405-8522
Giovanni Delli CarpiniWoman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona 60100, Italy.ORCID https://orcid.org/0000-0003-2849-4690
Andrea CiavattiniWoman's Health Sciences Department, Gynecologic Section, Polytechnic University of Marche, Ancona 60100, Italy.ORCID https://orcid.org/0000-0003-0074-5996
Marche Polytechnic University · ITHumanitas University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cervical cancer is relatively rare in high-income countries, where organized screening programs are in place, as well as opportunistic ones. As the human papillomavirus (HPV) vaccination rates increase, the prevalence of cervical precancers and cancers is going to decrease rapidly very soon, even if, in the most optimistic scenario, it is unlikely that optimal vaccination coverage will be achieved. Then, the optimal screening paradigm for cervical cancer prevention in the postvaccination era is still debated. Screening guidelines are being developed with the aim of reducing the number of tests a woman needs during her lifetime, in order to receive the maximum benefit from screening, while decreasing potential harms that may result with the use of a screening strategy (overdiagnosis, overtreatment, anxiety, and costs). With this purpose in mind, new management guidelines for cervical cancer screening abnormalities are recommendations based on risks, not on results. This review aims to summarize the process that led to the introduction of the HPV DNA test in screening programs and the different screening strategies. Moreover, it aims to introduce the new risk-based guidelines for the future, where full HPV genotyping can resize the risk on the basis of specific high-risk genotypes. In the same way, the data regarding HPV vaccination could be introduced as soon as women vaccinated with the nonavalent vaccine reach the screening age, with the recommendation of a prolonged screening interval.

Identifiers

PMID33204265
PMCPMC7661145
OpenAlexW3095486834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.