Evidence map›Paper›PMID 33204251›Full record

ArticleNeural plasticity2020

Developmental and Functional Hair Cell-Like Cells Induced by Atoh1 Overexpression in the Adult Mammalian Cochlea

Lingyi Kong, Yuan Xin, Fanglu Chi, Jie Chen, Juanmei Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. A NovelFrontiers in molecular neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lingyi Kong *Department of Otolaryngology, Shanghai Children's Medical Center, Shanghai JiaoTong University School of Medicine, Shanghai, China.ORCID 0000-0002-5398-0327
Yuan Xin *Department of Otolaryngology, Shanghai Children's Medical Center, Shanghai JiaoTong University School of Medicine, Shanghai, China.ORCID 0000-0002-6366-9639
Fanglu ChiDepartment of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-3243-0393
Jie ChenDepartment of Otolaryngology, Shanghai Children's Medical Center, Shanghai JiaoTong University School of Medicine, Shanghai, China.ORCID 0000-0003-0183-4835
Juanmei YangDepartment of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China.ORCID 0000-0001-5125-3532
Shanghai Jiao Tong University · CNFudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hair cells (HCs) in the mammalian cochleae cannot spontaneously regenerate once damaged, resulting in permanent hearing loss. It has been shown that Atoh1 overexpression induces hair cell-like cells (HCLCs) in the cochlea of newborn rodents, but this is hard to achieve in adult mammals. In this study, we used a three-dimensional cochlear culture system and an adenoviral-mediated delivery vector to overexpress Atoh1 in adult mouse cochleae. HCLCs were successfully induced from 3 days after virus infection (3 DVI)

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCochleaHair Cells, AuditoryMembrane PotentialsMice, Inbred C57BLAtoh1 protein, mouseBasic Helix-Loop-Helix Proteins

Identifiers

PMID33204251
PMCPMC7661126
OpenAlexW3095234551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.