Evidence map›Paper›PMID 33204219›Full record

ArticleMediators of inflammation2020

Expression Profiling of Long Noncoding RNA and Messenger RNA in a Cecal Ligation and Puncture-Induced Colon Injury Mouse Model.

Jinxiang Huang, Yuan Liu, Qingqiang Xie, Guorui Liang, Haifan Kong, Meiling Liu, Yujie Wang, Shanshan Zhang, Xuefeng Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jinxiang HuangThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, The State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0002-4065-0230
Yuan LiuThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, The State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0002-4159-1818
Qingqiang XieThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, The State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0001-9904-5804
Guorui LiangNan Shan School, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0003-4930-2547
Haifan KongNan Shan School, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0001-6973-1520
Meiling LiuThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, The State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0002-3130-4336
Yujie WangThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, The State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.
Shanshan ZhangDepartment of Gastroenterology, Affiliated Yantai Yuhuangding, Hospital of Qingdao University, Yantai 264000, China.ORCID https://orcid.org/0000-0003-2180-9979
Xuefeng LiThe Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, The State Key Laboratory of Respiratory Disease, Sino-French Hoffmann Institute, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.ORCID https://orcid.org/0000-0001-8146-8374
State Key Laboratory of Respiratory Disease · CNGuangzhou Medical University · CNShenzhen University · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmerging evidence reveals that long noncoding RNAs (lncRNAs) play important roles in the pathogenesis of sepsis. However, the detailed regulatory mechanisms of lncRNAs or whether certain lncRNA could serve as a biomarker in the septic colon remains unclear. The aim of this study was to investigate the profiles of lncRNAs and mRNAs in the septic colon through whole-transcriptome RNA sequencing and to reveal the associated regulatory mechanism. METHOD AND

resultWe established a mouse model of sepsis by cecal ligation and puncture (CLP). Colon samples were collected upon CLP or sham surgery after 24 h. Whole-transcriptome RNA sequencing was performed to profile the relative expressions of lncRNAs and mRNAs. 808 lncRNAs and 1509 mRNAs were differentially found in the septic group compared with the sham group. Bioinformatics analysis including Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes pathway analysis (KEGG) was performed to predict the potential functions of these RNAs. GO analysis showed that the altered lncRNAs were enriched and involved in multiple immune responses, which may be a response to sepsis stress. KEGG analysis indicated that upregulated lncRNAs were significantly enriched in the p53 signaling pathway, NF-

conclusionOur results indicate that these altered lncRNAs and mRNAs may have crucial roles in the pathogenesis of sepsis. This study could contribute to extending the understanding of the function of lncRNAs in sepsis, which may help in searching for new diagnostic biomarkers and therapeutic targets to treat sepsis.

Indexed as

Gene Expression ProfilingGene Expression RegulationAnimalsCecumColonComputational BiologyDisease Models, AnimalGene Regulatory NetworksIntestinesMiceMice, Inbred C57BLRNA, Long NoncodingRNA, MessengerSepsisSequence Analysis, RNASignal TransductionRNA, Long NoncodingRNA, Messenger

Identifiers

PMID33204219
PMCPMC7657679
OpenAlexW3095704751

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.