Evidence map›Paper›PMID 33204145›Full record

ArticleJournal of pain research2020

Ten kilohertz SCS for Treatment of Chronic Upper Extremity Pain (UEP): Results from Prospective Observational Study.

Abram Burgher, Peter Kosek, Steven Surrett, Steven M Rosen, Todd Bromberg, Ashish Gulve, Anu Kansal, Paul Wu, W Porter McRoberts, Ashish Udeshi and 5 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02703818 (Multi-Center, Prospective, Clinical Trial of the Senza™ Spinal Cord Stimulation), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02703818 nacompletednot on this map

Multi-Center, Prospective, Clinical Trial of the Senza™ Spinal Cord Stimulation (SCS) System in the Treatment Of Chronic Pain of the Upper Extremities

TypeinterventionalSponsorNevro CorpRan2016 to 2018Enrolled64ConditionsUpper Extremity PainArmsSenza
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Abram BurgherHope Research Institute, Phoenix, AZ, USA.
Peter KosekOregon Neurosurgery, Eugene, OR, USA.
Steven SurrettOregon Medical Group, Eugene, OR, USA.
Steven M RosenDelaware Valley Spine and Pain, Trevose, PA, USA.
Todd BrombergDelaware Valley Spine and Pain, Trevose, PA, USA.
Ashish GulveThe James Cook University Hospital, Middlesbrough, UK.ORCID 0000-0002-8137-4842
Anu KansalThe James Cook University Hospital, Middlesbrough, UK.
Paul WuHoly Cross Hospital, Inc., Ft, Lauderdale, FL, USA.
W Porter McRobertsHoly Cross Hospital, Inc., Ft, Lauderdale, FL, USA.ORCID 0000-0001-6852-8475
Ashish UdeshiFlorida Pain Institute, Merritt Island, FL, USA.ORCID 0000-0001-5492-1866
Michael EspositoFlorida Pain Institute, Merritt Island, FL, USA.
Bradford E GlinerNevro Corp., Redwood City, CA, USA.ORCID 0000-0002-8228-9439
Mona ManeshiNevro Corp., Redwood City, CA, USA.
Anand RotteNevro Corp., Redwood City, CA, USA.ORCID 0000-0002-3452-7068
Jeyakumar SubbaroyanNevro Corp., Redwood City, CA, USA.
Nevro (United States) · USDelaware Valley College · USFlorida Pain Institute · USHoly Cross Hospital · USJames Cook University Hospital · GBHope Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic upper extremity pain (UEP) has complex etiologies and is often disabling. It has been shown that 10 kHz SCS can provide paresthesia-free and durable pain relief in multiple pain types and improve the quality of life of patients.

objectiveTo gain additional evidence on the safety and effectiveness of 10 kHz SCS for the treatment of chronic UEP. STUDY

designIt was a prospective, multicenter, and observational study. The study was registered on ClinicalTrials.gov prospectively (clinical trial identifier: NCT02703818).

settingMulticenter. PATIENTS INTERVENTION AND MAIN OUTCOMES: A total of 43 subjects with chronic UEP of ≥5 cm (on a 0-10 cm visual analog scale; VAS) underwent a trial of 10 kHz SCS, and subjects with ≥40% pain relief received a permanent implant. All subjects had upper limb pain at baseline, while some had concomitant shoulder or neck pain. Subject outcomes were assessed for 12 months, and the primary outcome was the responder rate (percentage of subjects experiencing ≥50% pain relief from baseline) at three months.

resultsThirty-eight subjects successfully completed the trial (88.3% success rate), 33 received permanent implants (five withdrew consent), and 32 had device activation (per protocol population). There were no paresthesias or uncomfortable changes in stimulation related to changes in posture during the study and there were no neurological deficits. Responder rates at 12 months for upper limb, shoulder, and neck pain in per protocol population (N=32) were 78.1%, 85.2%, and 75.0%, respectively. At 12 months, 84.4% of subjects were satisfied or very satisfied with 10 kHz SCS, and 38.7% either reduced or eliminated opioid usage.

conclusionThis study further supports the effectiveness of 10 kHz SCS for chronic UEP treatment and documents the safety profile of the therapy. CLINICAL TRIAL IDENTIFIER: NCT02703818.

Indexed as

10 kHz SCSshoulder and upper limb painupper extremity painVAS

Identifiers

PMID33204145
PMCPMC7667505
OpenAlexW3101550811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.